Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 143721..144226 Replicon chromosome
Accession NZ_CP114374
Organism Pseudomonas aeruginosa strain Jade-X

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag O2604_RS00660 Protein ID WP_003083773.1
Coordinates 143721..144002 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag O2604_RS00665 Protein ID WP_003083775.1
Coordinates 143999..144226 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O2604_RS00635 (O2604_00635) 138972..140321 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
O2604_RS00640 (O2604_00640) 140370..141056 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
O2604_RS00645 (O2604_00645) 141157..141891 + 735 WP_003117208.1 GntR family transcriptional regulator -
O2604_RS00650 (O2604_00650) 142071..142481 + 411 WP_033937009.1 aegerolysin family protein -
O2604_RS00655 (O2604_00655) 142513..143421 - 909 WP_003083769.1 LysR family transcriptional regulator -
O2604_RS00660 (O2604_00660) 143721..144002 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
O2604_RS00665 (O2604_00665) 143999..144226 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
O2604_RS00670 (O2604_00670) 144402..145022 - 621 WP_003101226.1 hypothetical protein -
O2604_RS00675 (O2604_00675) 145123..145623 + 501 WP_003101228.1 LEA type 2 family protein -
O2604_RS00680 (O2604_00680) 145696..146037 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
O2604_RS00685 (O2604_00685) 146119..147546 - 1428 WP_088170997.1 GABA permease -
O2604_RS00690 (O2604_00690) 147715..149208 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T266633 WP_003083773.1 NZ_CP114374:c144002-143721 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT266633 WP_003083775.1 NZ_CP114374:c144226-143999 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References