Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
| Location | 5170721..5172402 | Replicon | chromosome |
| Accession | NZ_CP114361 | ||
| Organism | Klebsiella variicola strain 2022CK-00568 | ||
Toxin (Protein)
| Gene name | mosT | Uniprot ID | A0A1F2M1V2 |
| Locus tag | OPU52_RS25080 | Protein ID | WP_032734038.1 |
| Coordinates | 5170721..5171638 (-) | Length | 306 a.a. |
Antitoxin (Protein)
| Gene name | mosA | Uniprot ID | - |
| Locus tag | OPU52_RS25085 | Protein ID | WP_110242892.1 |
| Coordinates | 5171644..5172402 (-) | Length | 253 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| OPU52_RS25060 (OPU52_25055) | 5166027..5167547 | + | 1521 | WP_110242893.1 | sugar ABC transporter ATP-binding protein | - |
| OPU52_RS25065 (OPU52_25060) | 5167544..5168542 | + | 999 | WP_023296904.1 | ribose ABC transporter permease | - |
| OPU52_RS25070 (OPU52_25065) | 5168573..5169514 | + | 942 | WP_012543155.1 | ABC transporter substrate-binding protein | - |
| OPU52_RS25075 (OPU52_25070) | 5169589..5170596 | + | 1008 | WP_022065799.1 | carbohydrate kinase family protein | - |
| OPU52_RS25080 (OPU52_25075) | 5170721..5171638 | - | 918 | WP_032734038.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| OPU52_RS25085 (OPU52_25080) | 5171644..5172402 | - | 759 | WP_110242892.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
| OPU52_RS25090 (OPU52_25085) | 5172487..5173215 | - | 729 | WP_008807258.1 | response regulator transcription factor | - |
| OPU52_RS25095 (OPU52_25090) | 5173488..5175635 | + | 2148 | WP_077625453.1 | formate dehydrogenase subunit alpha | - |
| OPU52_RS25100 (OPU52_25095) | 5175989..5176675 | + | 687 | WP_008807260.1 | tetratricopeptide repeat protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34733.10 Da Isoelectric Point: 5.4707
>T266623 WP_032734038.1 NZ_CP114361:c5171638-5170721 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28657.94 Da Isoelectric Point: 10.1988
>AT266623 WP_110242892.1 NZ_CP114361:c5172402-5171644 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|