Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1724071..1725068 Replicon chromosome
Accession NZ_CP114361
Organism Klebsiella variicola strain 2022CK-00568

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OPU52_RS08410 Protein ID WP_229531768.1
Coordinates 1724514..1725068 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag OPU52_RS08405 Protein ID WP_012541033.1
Coordinates 1724071..1724517 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU52_RS08390 (OPU52_08390) 1720366..1721364 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
OPU52_RS08395 (OPU52_08395) 1721483..1723003 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
OPU52_RS08400 (OPU52_08400) 1723019..1724029 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
OPU52_RS08405 (OPU52_08405) 1724071..1724517 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
OPU52_RS08410 (OPU52_08410) 1724514..1725068 - 555 WP_229531768.1 HipA domain-containing protein Toxin
OPU52_RS08415 (OPU52_08415) 1725097..1725618 - 522 WP_025714688.1 hypothetical protein -
OPU52_RS08420 (OPU52_08420) 1725733..1726464 - 732 WP_008804033.1 outer membrane permeability protein SanA -
OPU52_RS08425 (OPU52_08425) 1726757..1727641 - 885 WP_262266825.1 cytidine deaminase -
OPU52_RS08430 (OPU52_08430) 1727770..1728465 - 696 WP_061153873.1 CidB/LrgB family autolysis modulator -
OPU52_RS08435 (OPU52_08435) 1728455..1728859 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20710.03 Da        Isoelectric Point: 5.7891

>T266613 WP_229531768.1 NZ_CP114361:c1725068-1724514 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT266613 WP_012541033.1 NZ_CP114361:c1724517-1724071 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References