Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795087..795744 Replicon chromosome
Accession NZ_CP114361
Organism Klebsiella variicola strain 2022CK-00568

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OPU52_RS03915 Protein ID WP_002916310.1
Coordinates 795334..795744 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OPU52_RS03910 Protein ID WP_002916312.1
Coordinates 795087..795353 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU52_RS03885 (OPU52_03885) 791529..792257 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
OPU52_RS03890 (OPU52_03890) 792308..792619 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
OPU52_RS03895 (OPU52_03895) 792783..793442 + 660 WP_008806429.1 hemolysin III family protein -
OPU52_RS03900 (OPU52_03900) 793473..793811 + 339 WP_145940792.1 hypothetical protein -
OPU52_RS03905 (OPU52_03905) 793858..794841 - 984 WP_023340714.1 tRNA-modifying protein YgfZ -
OPU52_RS03910 (OPU52_03910) 795087..795353 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OPU52_RS03915 (OPU52_03915) 795334..795744 + 411 WP_002916310.1 protein YgfX Toxin
OPU52_RS03920 (OPU52_03920) 795751..796272 - 522 WP_008806427.1 flavodoxin FldB -
OPU52_RS03925 (OPU52_03925) 796373..797269 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
OPU52_RS03930 (OPU52_03930) 797292..798005 + 714 WP_012540593.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OPU52_RS03935 (OPU52_03935) 798011..799744 + 1734 WP_032736401.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T266612 WP_002916310.1 NZ_CP114361:795334-795744 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT266612 WP_002916312.1 NZ_CP114361:795087-795353 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References