Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2844243..2845837 Replicon chromosome
Accession NZ_CP114354
Organism Klebsiella variicola strain 2022CK-00567

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OPU51_RS13885 Protein ID WP_101827469.1
Coordinates 2844243..2845571 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2V3KHJ7
Locus tag OPU51_RS13890 Protein ID WP_038422544.1
Coordinates 2845571..2845837 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OPU51_RS13870 (OPU51_13875) 2840476..2841480 + 1005 WP_032730346.1 fimbrial protein -
OPU51_RS13875 (OPU51_13880) 2841613..2842905 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
OPU51_RS13880 (OPU51_13885) 2843040..2844044 + 1005 WP_000427614.1 IS110-like element IS5075 family transposase -
OPU51_RS13885 (OPU51_13890) 2844243..2845571 - 1329 WP_101827469.1 type II toxin-antitoxin system HipA family toxin Toxin
OPU51_RS13890 (OPU51_13895) 2845571..2845837 - 267 WP_038422544.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OPU51_RS13895 (OPU51_13900) 2846103..2846429 - 327 WP_008804921.1 hydroxyisourate hydrolase -
OPU51_RS13900 (OPU51_13905) 2846426..2846926 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OPU51_RS13905 (OPU51_13910) 2846904..2848283 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
OPU51_RS13910 (OPU51_13915) 2848629..2849783 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
OPU51_RS13915 (OPU51_13920) 2849764..2850687 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2843040..2844044 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48997.39 Da        Isoelectric Point: 7.2497

>T266601 WP_101827469.1 NZ_CP114354:c2845571-2844243 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGELMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITESMVTPVFATPILTTSWLA

Download         Length: 1329 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9923.30 Da        Isoelectric Point: 8.5912

>AT266601 WP_038422544.1 NZ_CP114354:c2845837-2845571 [Klebsiella variicola]
MTSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3KHJ7

References