Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | mosAT/AbiEii-AbiEi |
Location | 5170722..5172403 | Replicon | chromosome |
Accession | NZ_CP114328 | ||
Organism | Klebsiella variicola strain 2022CK-00504 |
Toxin (Protein)
Gene name | mosT | Uniprot ID | A0A1F2M1V2 |
Locus tag | OEE49_RS25080 | Protein ID | WP_032734038.1 |
Coordinates | 5170722..5171639 (-) | Length | 306 a.a. |
Antitoxin (Protein)
Gene name | mosA | Uniprot ID | - |
Locus tag | OEE49_RS25085 | Protein ID | WP_110242892.1 |
Coordinates | 5171645..5172403 (-) | Length | 253 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OEE49_RS25060 (OEE49_25055) | 5166028..5167548 | + | 1521 | WP_110242893.1 | sugar ABC transporter ATP-binding protein | - |
OEE49_RS25065 (OEE49_25060) | 5167545..5168543 | + | 999 | WP_023296904.1 | ribose ABC transporter permease | - |
OEE49_RS25070 (OEE49_25065) | 5168574..5169515 | + | 942 | WP_012543155.1 | ABC transporter substrate-binding protein | - |
OEE49_RS25075 (OEE49_25070) | 5169590..5170597 | + | 1008 | WP_022065799.1 | carbohydrate kinase family protein | - |
OEE49_RS25080 (OEE49_25075) | 5170722..5171639 | - | 918 | WP_032734038.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
OEE49_RS25085 (OEE49_25080) | 5171645..5172403 | - | 759 | WP_110242892.1 | type IV toxin-antitoxin system AbiEi family antitoxin | Antitoxin |
OEE49_RS25090 (OEE49_25085) | 5172488..5173216 | - | 729 | WP_008807258.1 | response regulator transcription factor | - |
OEE49_RS25095 (OEE49_25090) | 5173489..5175636 | + | 2148 | WP_077625453.1 | formate dehydrogenase subunit alpha | - |
OEE49_RS25100 (OEE49_25095) | 5175990..5176676 | + | 687 | WP_008807260.1 | tetratricopeptide repeat protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
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Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 306 a.a. Molecular weight: 34733.10 Da Isoelectric Point: 5.4707
>T266566 WP_032734038.1 NZ_CP114328:c5171639-5170722 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS
Download Length: 918 bp
Antitoxin
Download Length: 253 a.a. Molecular weight: 28657.94 Da Isoelectric Point: 10.1988
>AT266566 WP_110242892.1 NZ_CP114328:c5172403-5171645 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE
Download Length: 759 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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