Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1722872..1723869 Replicon chromosome
Accession NZ_CP114320
Organism Klebsiella variicola strain 2022CK-00502

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OEE46_RS08405 Protein ID WP_229531768.1
Coordinates 1723315..1723869 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag OEE46_RS08400 Protein ID WP_012541033.1
Coordinates 1722872..1723318 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE46_RS08385 (OEE46_08385) 1719167..1720165 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
OEE46_RS08390 (OEE46_08390) 1720284..1721804 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
OEE46_RS08395 (OEE46_08395) 1721820..1722830 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
OEE46_RS08400 (OEE46_08400) 1722872..1723318 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
OEE46_RS08405 (OEE46_08405) 1723315..1723869 - 555 WP_229531768.1 HipA domain-containing protein Toxin
OEE46_RS08410 (OEE46_08410) 1723898..1724419 - 522 WP_025714688.1 hypothetical protein -
OEE46_RS08415 (OEE46_08415) 1724534..1725265 - 732 WP_008804033.1 outer membrane permeability protein SanA -
OEE46_RS08420 (OEE46_08420) 1725558..1726442 - 885 WP_262266825.1 cytidine deaminase -
OEE46_RS08425 (OEE46_08425) 1726571..1727266 - 696 WP_061153873.1 CidB/LrgB family autolysis modulator -
OEE46_RS08430 (OEE46_08430) 1727256..1727660 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20710.03 Da        Isoelectric Point: 5.7891

>T266518 WP_229531768.1 NZ_CP114320:c1723869-1723315 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT266518 WP_012541033.1 NZ_CP114320:c1723318-1722872 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References