Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795088..795745 Replicon chromosome
Accession NZ_CP114320
Organism Klebsiella variicola strain 2022CK-00502

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OEE46_RS03915 Protein ID WP_002916310.1
Coordinates 795335..795745 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OEE46_RS03910 Protein ID WP_002916312.1
Coordinates 795088..795354 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE46_RS03885 (OEE46_03885) 791530..792258 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
OEE46_RS03890 (OEE46_03890) 792309..792620 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
OEE46_RS03895 (OEE46_03895) 792784..793443 + 660 WP_008806429.1 hemolysin III family protein -
OEE46_RS03900 (OEE46_03900) 793474..793812 + 339 WP_145940792.1 hypothetical protein -
OEE46_RS03905 (OEE46_03905) 793859..794842 - 984 WP_023340714.1 tRNA-modifying protein YgfZ -
OEE46_RS03910 (OEE46_03910) 795088..795354 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OEE46_RS03915 (OEE46_03915) 795335..795745 + 411 WP_002916310.1 protein YgfX Toxin
OEE46_RS03920 (OEE46_03920) 795752..796273 - 522 WP_008806427.1 flavodoxin FldB -
OEE46_RS03925 (OEE46_03925) 796374..797270 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
OEE46_RS03930 (OEE46_03930) 797293..798006 + 714 WP_012540593.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEE46_RS03935 (OEE46_03935) 798012..799745 + 1734 WP_032736401.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T266517 WP_002916310.1 NZ_CP114320:795335-795745 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT266517 WP_002916312.1 NZ_CP114320:795088-795354 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References