Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5169522..5171203 Replicon chromosome
Accession NZ_CP114312
Organism Klebsiella variicola strain 2022CK-00500

Toxin (Protein)


Gene name mosT Uniprot ID A0A1F2M1V2
Locus tag OEE47_RS25070 Protein ID WP_032734038.1
Coordinates 5169522..5170439 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag OEE47_RS25075 Protein ID WP_110242892.1
Coordinates 5170445..5171203 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE47_RS25050 (OEE47_25045) 5164828..5166348 + 1521 WP_110242893.1 sugar ABC transporter ATP-binding protein -
OEE47_RS25055 (OEE47_25050) 5166345..5167343 + 999 WP_023296904.1 ribose ABC transporter permease -
OEE47_RS25060 (OEE47_25055) 5167374..5168315 + 942 WP_012543155.1 ABC transporter substrate-binding protein -
OEE47_RS25065 (OEE47_25060) 5168390..5169397 + 1008 WP_022065799.1 carbohydrate kinase family protein -
OEE47_RS25070 (OEE47_25065) 5169522..5170439 - 918 WP_032734038.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OEE47_RS25075 (OEE47_25070) 5170445..5171203 - 759 WP_110242892.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OEE47_RS25080 (OEE47_25075) 5171288..5172016 - 729 WP_008807258.1 response regulator transcription factor -
OEE47_RS25085 (OEE47_25080) 5172289..5174436 + 2148 WP_077625453.1 formate dehydrogenase subunit alpha -
OEE47_RS25090 (OEE47_25085) 5174790..5175476 + 687 WP_008807260.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34733.10 Da        Isoelectric Point: 5.4707

>T266490 WP_032734038.1 NZ_CP114312:c5170439-5169522 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28657.94 Da        Isoelectric Point: 10.1988

>AT266490 WP_110242892.1 NZ_CP114312:c5171203-5170445 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1F2M1V2


Antitoxin

Source ID Structure

References