Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4696382..4697201 Replicon chromosome
Accession NZ_CP114308
Organism Klebsiella oxytoca strain 2022CK-00499

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag OEE41_RS22105 Protein ID WP_004110819.1
Coordinates 4696944..4697201 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag OEE41_RS22100 Protein ID WP_142472422.1
Coordinates 4696382..4696933 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE41_RS22070 (OEE41_22060) 4692403..4692774 + 372 WP_269776307.1 cyclophilin-like fold protein -
OEE41_RS22075 (OEE41_22065) 4693559..4693900 + 342 Protein_4344 alcohol dehydrogenase catalytic domain-containing protein -
OEE41_RS22080 (OEE41_22070) 4694154..4694357 - 204 Protein_4345 VOC family protein -
OEE41_RS22085 (OEE41_22075) 4694357..4694566 - 210 WP_196089984.1 hypothetical protein -
OEE41_RS22090 (OEE41_22080) 4694736..4695500 - 765 WP_227499114.1 class I SAM-dependent methyltransferase -
OEE41_RS22095 (OEE41_22085) 4695894..4696268 - 375 Protein_4348 class I SAM-dependent methyltransferase -
OEE41_RS22100 (OEE41_22090) 4696382..4696933 - 552 WP_142472422.1 N-acetyltransferase Antitoxin
OEE41_RS22105 (OEE41_22095) 4696944..4697201 - 258 WP_004110819.1 YjhX family toxin Toxin
OEE41_RS22110 (OEE41_22100) 4697783..4698967 + 1185 WP_004099225.1 mannonate dehydratase -
OEE41_RS22115 (OEE41_22105) 4699042..4700517 + 1476 WP_004110817.1 fructuronate reductase -
OEE41_RS22120 (OEE41_22110) 4700653..4701429 + 777 WP_004099223.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(17-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T266474 WP_004110819.1 NZ_CP114308:c4697201-4696944 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20213.02 Da        Isoelectric Point: 6.7181

>AT266474 WP_142472422.1 NZ_CP114308:c4696933-4696382 [Klebsiella oxytoca]
MTNHNFTFHITSERDADDIREVETRAFGFSKEADLVADLLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References