Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4448018..4448637 Replicon chromosome
Accession NZ_CP114308
Organism Klebsiella oxytoca strain 2022CK-00499

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag OEE41_RS20935 Protein ID WP_004099646.1
Coordinates 4448419..4448637 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag OEE41_RS20930 Protein ID WP_004099648.1
Coordinates 4448018..4448392 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE41_RS20920 (OEE41_20910) 4443173..4444366 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OEE41_RS20925 (OEE41_20915) 4444389..4447535 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
OEE41_RS20930 (OEE41_20920) 4448018..4448392 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
OEE41_RS20935 (OEE41_20925) 4448419..4448637 + 219 WP_004099646.1 HHA domain-containing protein Toxin
OEE41_RS20940 (OEE41_20930) 4448798..4449364 + 567 WP_004099644.1 maltose O-acetyltransferase -
OEE41_RS20945 (OEE41_20935) 4449333..4449470 - 138 WP_224226720.1 hypothetical protein -
OEE41_RS20950 (OEE41_20940) 4449501..4449971 + 471 WP_004099643.1 YlaC family protein -
OEE41_RS20955 (OEE41_20945) 4449946..4451401 - 1456 Protein_4122 PLP-dependent aminotransferase family protein -
OEE41_RS20960 (OEE41_20950) 4451504..4452202 + 699 WP_004099639.1 GNAT family protein -
OEE41_RS20965 (OEE41_20955) 4452199..4452339 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OEE41_RS20970 (OEE41_20960) 4452339..4452602 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T266473 WP_004099646.1 NZ_CP114308:4448419-4448637 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT266473 WP_004099648.1 NZ_CP114308:4448018-4448392 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References