Detailed information of TA system TA026647

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2218341..2218870
• Replicon: chromosome
• Accession: NC_017341
• Organism: Staphylococcus aureus subsp. aureus str. JKD6008

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: SAA6008_RS11375
• Protein ID: WP_000621175.1
• Coordinates: 2218341..2218703 (-)
• Length: 121 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: T1YCG8
• Locus tag: SAA6008_RS11380
• Protein ID: WP_000948331.1
• Coordinates: 2218700..2218870 (-)
• Length: 57 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6008_RS11350	2215320..2216090	-	771	WP_001041103.1	RNA polymerase sigma factor SigB	-
SAA6008_RS11355	2216065..2216544	-	480	WP_001190829.1	anti-sigma B factor RsbW	-
SAA6008_RS11360	2216546..2216872	-	327	WP_001052491.1	anti-sigma factor antagonist	-
SAA6008_RS11365	2216991..2217992	-	1002	WP_000390829.1	PP2C family protein-serine/threonine phosphatase	-
SAA6008_RS11375	2218341..2218703	-	363	WP_000621175.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
SAA6008_RS11380	2218700..2218870	-	171	WP_000948331.1	type II toxin-antitoxin system antitoxin MazE	Antitoxin
SAA6008_RS11385	2218955..2220103	-	1149	WP_001281145.1	alanine racemase	-
SAA6008_RS11390	2220169..2220528	-	360	WP_000581200.1	holo-ACP synthase	-
SAA6008_RS11395	2220532..2221023	-	492	WP_001205910.1	PH domain-containing protein	-
SAA6008_RS11400	2221010..2222593	-	1584	WP_001294626.1	PH domain-containing protein	-
SAA6008_RS11405	2222586..2223065	-	480	WP_001287088.1	hypothetical protein	-
SAA6008_RS11410	2223273..2223833	-	561	WP_001092411.1	K(+)-transporting ATPase subunit C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-110)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 121 a.a.
• Molecular weight: 13441.69 Da
• Isoelectric Point: 10.1654

>T26647 WP_000621175.1 NC_017341:c2218703-2218341 [Staphylococcus aureus subsp. aureus str. JKD6008]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIEKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSDDKMKEVDNALMISLGLNAVAHQKN

Nucleotide

• Length: 363 bp

>T26647 NC_017341:c2218703-2218341 [Staphylococcus aureus subsp. aureus str. JKD6008]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAGTTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCACCAGAAAAATTAG

Antitoxin

Protein

• Length: 57 a.a.
• Molecular weight: 6251.78 Da
• Isoelectric Point: 3.8305

>AT26647 WP_000948331.1 NC_017341:c2218870-2218700 [Staphylococcus aureus subsp. aureus str. JKD6008]
MLSFSQNRSHSLEQSLKEGYSQMADLNLSLANEAFPIECEACDCNETYLSSNSTNE

Nucleotide

• Length: 171 bp

>AT26647 NC_017341:c2218870-2218700 [Staphylococcus aureus subsp. aureus str. JKD6008]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Structures

Antitoxin

• AlphaFold DB: A0A0E0VRZ1