Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX(toxin)
Location 4584396..4585215 Replicon chromosome
Accession NZ_CP114305
Organism Klebsiella oxytoca strain 2022CK-00498

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag OGU21_RS21620 Protein ID WP_004110819.1
Coordinates 4584958..4585215 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag OGU21_RS21615 Protein ID WP_023329286.1
Coordinates 4584396..4584947 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGU21_RS21590 (OGU21_21590) 4579466..4580014 - 549 WP_004099233.1 type 1 fimbrial major subunit FimA -
OGU21_RS21595 (OGU21_21595) 4580387..4581154 + 768 WP_004099232.1 winged helix-turn-helix domain-containing protein -
OGU21_RS21600 (OGU21_21600) 4581782..4582459 + 678 WP_023329288.1 sigma-70 region 4 domain-containing protein -
OGU21_RS21605 (OGU21_21605) 4582750..4583514 - 765 WP_224227635.1 class I SAM-dependent methyltransferase -
OGU21_RS21610 (OGU21_21610) 4583890..4584282 - 393 Protein_4250 class I SAM-dependent methyltransferase -
OGU21_RS21615 (OGU21_21615) 4584396..4584947 - 552 WP_023329286.1 N-acetyltransferase Antitoxin
OGU21_RS21620 (OGU21_21620) 4584958..4585215 - 258 WP_004110819.1 YjhX family toxin Toxin
OGU21_RS21625 (OGU21_21625) 4585797..4586981 + 1185 WP_004099225.1 mannonate dehydratase -
OGU21_RS21630 (OGU21_21630) 4587056..4588531 + 1476 WP_047720344.1 fructuronate reductase -
OGU21_RS21635 (OGU21_21635) 4588667..4589443 + 777 WP_004099223.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T266465 WP_004110819.1 NZ_CP114305:c4585215-4584958 [Klebsiella oxytoca]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 20125.00 Da        Isoelectric Point: 7.0635

>AT266465 WP_023329286.1 NZ_CP114305:c4584947-4584396 [Klebsiella oxytoca]
MTNHNFTFHITSERDAADIREVETRAFGFSKEADLVAALLNDESAHPSLSLLAKHNGKAVGHILFTLATFKGESDSPMMH
ILAPLAVVPEYQGVGVGGLLIQRGIEHLKAAGSEAVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMLQRLSS
RPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References