Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4345637..4346256 Replicon chromosome
Accession NZ_CP114305
Organism Klebsiella oxytoca strain 2022CK-00498

Toxin (Protein)


Gene name Hha Uniprot ID H3N9D8
Locus tag OGU21_RS20490 Protein ID WP_004099646.1
Coordinates 4346038..4346256 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag OGU21_RS20485 Protein ID WP_004099648.1
Coordinates 4345637..4346011 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGU21_RS20475 (OGU21_20475) 4340793..4341986 + 1194 WP_004111040.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
OGU21_RS20480 (OGU21_20480) 4342009..4345155 + 3147 WP_004099650.1 multidrug efflux RND transporter permease subunit AcrB -
OGU21_RS20485 (OGU21_20485) 4345637..4346011 + 375 WP_004099648.1 Hha toxicity modulator TomB Antitoxin
OGU21_RS20490 (OGU21_20490) 4346038..4346256 + 219 WP_004099646.1 HHA domain-containing protein Toxin
OGU21_RS20495 (OGU21_20495) 4346417..4346983 + 567 WP_004099644.1 maltose O-acetyltransferase -
OGU21_RS20500 (OGU21_20500) 4346952..4347089 - 138 WP_224226720.1 hypothetical protein -
OGU21_RS20505 (OGU21_20505) 4347120..4347590 + 471 WP_004111038.1 YlaC family protein -
OGU21_RS20510 (OGU21_20510) 4347565..4349019 - 1455 WP_070557208.1 PLP-dependent aminotransferase family protein -
OGU21_RS20515 (OGU21_20515) 4349122..4349820 + 699 WP_004099639.1 GNAT family protein -
OGU21_RS20520 (OGU21_20520) 4349817..4349957 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
OGU21_RS20525 (OGU21_20525) 4349957..4350220 - 264 WP_004099638.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8640.05 Da        Isoelectric Point: 8.9008

>T266464 WP_004099646.1 NZ_CP114305:4346038-4346256 [Klebsiella oxytoca]
MSDKTLTKIDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPPSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14350.09 Da        Isoelectric Point: 4.8989

>AT266464 WP_004099648.1 NZ_CP114305:4345637-4346011 [Klebsiella oxytoca]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIAAFALNYKIKYAEDNKLVTQLDEYL
DDTFVLFSNYGINTADLQKWRKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H713

Antitoxin

Source ID Structure

References