Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 889895..890552 Replicon chromosome
Accession NZ_CP114305
Organism Klebsiella oxytoca strain 2022CK-00498

Toxin (Protein)


Gene name cptA Uniprot ID A0A181X6I0
Locus tag OGU21_RS04300 Protein ID WP_004105559.1
Coordinates 890142..890552 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A285B945
Locus tag OGU21_RS04295 Protein ID WP_004105561.1
Coordinates 889895..890161 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGU21_RS04270 (OGU21_04275) 885074..886507 - 1434 WP_004105576.1 6-phospho-beta-glucosidase -
OGU21_RS04275 (OGU21_04280) 886628..887356 - 729 WP_064352017.1 MurR/RpiR family transcriptional regulator -
OGU21_RS04280 (OGU21_04285) 887407..887718 + 312 WP_017145456.1 N(4)-acetylcytidine aminohydrolase -
OGU21_RS04285 (OGU21_04290) 887880..888539 + 660 WP_064344096.1 hemolysin III family protein -
OGU21_RS04290 (OGU21_04295) 888668..889651 - 984 WP_224261472.1 tRNA-modifying protein YgfZ -
OGU21_RS04295 (OGU21_04300) 889895..890161 + 267 WP_004105561.1 FAD assembly factor SdhE Antitoxin
OGU21_RS04300 (OGU21_04305) 890142..890552 + 411 WP_004105559.1 protein YgfX Toxin
OGU21_RS04305 (OGU21_04310) 890561..891082 - 522 WP_004105557.1 flavodoxin FldB -
OGU21_RS04310 (OGU21_04315) 891204..892100 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
OGU21_RS04315 (OGU21_04320) 892123..892836 + 714 WP_004105554.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OGU21_RS04320 (OGU21_04325) 892842..894575 + 1734 WP_024274698.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16061.83 Da        Isoelectric Point: 10.9455

>T266458 WP_004105559.1 NZ_CP114305:890142-890552 [Klebsiella oxytoca]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLVLPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIVGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLQKPTQD

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10555.02 Da        Isoelectric Point: 5.1498

>AT266458 WP_004105561.1 NZ_CP114305:889895-890161 [Klebsiella oxytoca]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDDDKRLFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A181X6I0

Antitoxin

Source ID Structure
AlphaFold DB A0A285B945

References