Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 673391..673983 Replicon chromosome
Accession NZ_CP114305
Organism Klebsiella oxytoca strain 2022CK-00498

Toxin (Protein)


Gene name doc Uniprot ID A0A7H4PHG5
Locus tag OGU21_RS03265 Protein ID WP_004105955.1
Coordinates 673609..673983 (+) Length 125 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A2J4YM08
Locus tag OGU21_RS03260 Protein ID WP_004105957.1
Coordinates 673391..673612 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGU21_RS03240 (OGU21_03245) 668952..669506 + 555 WP_004105965.1 YgjV family protein -
OGU21_RS03245 (OGU21_03250) 669521..670768 - 1248 WP_004105963.1 serine/threonine transporter SstT -
OGU21_RS03250 (OGU21_03255) 671023..671991 - 969 WP_004115718.1 TerC family protein -
OGU21_RS03255 (OGU21_03260) 672242..673231 - 990 WP_070556310.1 Gfo/Idh/MocA family oxidoreductase -
OGU21_RS03260 (OGU21_03265) 673391..673612 + 222 WP_004105957.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
OGU21_RS03265 (OGU21_03270) 673609..673983 + 375 WP_004105955.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
OGU21_RS03270 (OGU21_03275) 673963..674466 - 504 WP_070556312.1 M48 family metallopeptidase -
OGU21_RS03275 (OGU21_03280) 674545..676188 - 1644 WP_004115710.1 glycoside hydrolase family 43 protein -
OGU21_RS03280 (OGU21_03285) 676317..677183 - 867 WP_004105950.1 AraC family transcriptional regulator -
OGU21_RS03285 (OGU21_03290) 677291..678634 + 1344 WP_004105949.1 glycoside-pentoside-hexuronide (GPH):cation symporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(5-119)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-52)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13895.93 Da        Isoelectric Point: 6.0769

>T266457 WP_004105955.1 NZ_CP114305:673609-673983 [Klebsiella oxytoca]
MKWVSASEVIAFHDRILQHLPGVKGMSDPGRAEAIIYRVQNRFHYEGVNDIFELAATYWVAIARGHIFNDGNKRTAFFIT
MTFLARNGYLIADEDTRLEELTVLAATGEATVVVLADALRQLAL

Download         Length: 375 bp

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8185.19 Da        Isoelectric Point: 5.7996

>AT266457 WP_004105957.1 NZ_CP114305:673391-673612 [Klebsiella oxytoca]
MRSYSTSEARQNIAAVMDAAASGEPIEITRRDGTSNVLISKAEYETFMNAKLDAEFDFIMQRHGRTVKALTDR

Download         Length: 222 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H4PHG5

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4YM08

References