Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 60869..61416 Replicon chromosome
Accession NZ_CP114305
Organism Klebsiella oxytoca strain 2022CK-00498

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag OGU21_RS00300 Protein ID WP_070556473.1
Coordinates 60869..61177 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag OGU21_RS00305 Protein ID WP_064344020.1
Coordinates 61180..61416 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OGU21_RS00275 (OGU21_00275) 56773..57084 - 312 WP_004107048.1 PTS sugar transporter subunit IIB -
OGU21_RS00280 (OGU21_00280) 57379..58320 + 942 WP_004107045.1 LacI family DNA-binding transcriptional regulator -
OGU21_RS00285 (OGU21_00285) 58344..58640 - 297 WP_004116571.1 YicS family protein -
OGU21_RS00290 (OGU21_00290) 58851..59813 + 963 Protein_57 Rpn family recombination-promoting nuclease/putative transposase -
OGU21_RS00295 (OGU21_00295) 59817..60719 - 903 WP_004107039.1 DMT family transporter -
OGU21_RS00300 (OGU21_00300) 60869..61177 - 309 WP_070556473.1 CcdB family protein Toxin
OGU21_RS00305 (OGU21_00305) 61180..61416 - 237 WP_064344020.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
OGU21_RS00310 (OGU21_00310) 61522..62955 - 1434 WP_064370664.1 PTS N-acetylmuramic acid transporter subunit IIBC -
OGU21_RS00315 (OGU21_00315) 62980..63882 - 903 WP_134883454.1 N-acetylmuramic acid 6-phosphate etherase -
OGU21_RS00320 (OGU21_00320) 64044..65210 - 1167 WP_004107034.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 58848..59048 200


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11683.48 Da        Isoelectric Point: 5.6023

>T266454 WP_070556473.1 NZ_CP114305:c61177-60869 [Klebsiella oxytoca]
MQYYVYKNTGRIAAYPYLLDVQSDIIGERNTRVVIPLFPLKNYKGPLADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8768.95 Da        Isoelectric Point: 5.7928

>AT266454 WP_064344020.1 NZ_CP114305:c61416-61180 [Klebsiella oxytoca]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENALAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References