Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1243732..1244378 Replicon chromosome
Accession NZ_CP114281
Organism Gallibacterium anatis strain ESV200

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag CF557_RS05865 Protein ID WP_094871717.1
Coordinates 1243732..1244139 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A0A2Z0K5
Locus tag CF557_RS05870 Protein ID WP_021461268.1
Coordinates 1244139..1244378 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF557_RS05845 (CF557_05845) 1238820..1238981 - 162 WP_179256201.1 hypothetical protein -
CF557_RS05850 (CF557_05850) 1239182..1240300 - 1119 WP_094871715.1 iron-sulfur cluster carrier protein ApbC -
CF557_RS05855 (CF557_05855) 1240498..1242543 + 2046 WP_039148672.1 methionine--tRNA ligase -
CF557_RS05860 (CF557_05860) 1242628..1243632 + 1005 WP_013746892.1 16S rRNA (guanine(1207)-N(2))-methyltransferase RsmC -
CF557_RS05865 (CF557_05865) 1243732..1244139 - 408 WP_094871717.1 tRNA(fMet)-specific endonuclease VapC Toxin
CF557_RS05870 (CF557_05870) 1244139..1244378 - 240 WP_021461268.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
CF557_RS05875 (CF557_05875) 1244670..1245665 + 996 WP_094871720.1 thiamine ABC transporter substrate binding subunit -
CF557_RS05880 (CF557_05880) 1245641..1247263 + 1623 WP_094871722.1 thiamine/thiamine pyrophosphate ABC transporter permease -
CF557_RS05885 (CF557_05885) 1247250..1247912 + 663 WP_094871724.1 thiamine ABC transporter ATP-binding protein -
CF557_RS05890 (CF557_05890) 1247952..1248962 + 1011 WP_039083518.1 biotin synthase BioB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15105.64 Da        Isoelectric Point: 7.8732

>T266450 WP_094871717.1 NZ_CP114281:c1244139-1243732 [Gallibacterium anatis]
MLKYMLDTNIVIFTIKNKPPHLLPLFNENQSMLCISSITLMELVYGAEKSKKTAQNLAVIESFCARLAVLDYDEAAAYHS
GQIRAELAKIRQPIGSYDAMIAGHARSLGLTVVTNNMNEFSRVEGLRVIDWSKPM

Download         Length: 408 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9043.25 Da        Isoelectric Point: 4.4013

>AT266450 WP_021461268.1 NZ_CP114281:c1244378-1244139 [Gallibacterium anatis]
MSVVTATVFMNNKSQAIRIPKAAELPNTTKSVNIIIQGDMRIITPLNNVWDSWFNDSNSVSDDFMLSREQPQMQEREEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2Z0K5

References