Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 1196397..1196942 Replicon chromosome
Accession NZ_CP114281
Organism Gallibacterium anatis strain ESV200

Toxin (Protein)


Gene name relE Uniprot ID F4HF99
Locus tag CF557_RS05635 Protein ID WP_013746939.1
Coordinates 1196397..1196684 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A2ZZB6
Locus tag CF557_RS05640 Protein ID WP_039087491.1
Coordinates 1196694..1196942 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF557_RS05605 (CF557_05605) 1191670..1192596 + 927 WP_039083772.1 phosphoserine phosphatase -
CF557_RS05610 (CF557_05610) 1192609..1193100 + 492 WP_013746944.1 YajQ family cyclic di-GMP-binding protein -
CF557_RS05615 (CF557_05615) 1193122..1193289 + 168 WP_018345760.1 DUF5363 family protein -
CF557_RS05620 (CF557_05620) 1193374..1195389 + 2016 WP_094873352.1 NAD-dependent DNA ligase LigA -
CF557_RS05625 (CF557_05625) 1195594..1195860 + 267 WP_018345762.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CF557_RS05630 (CF557_05630) 1195860..1196213 + 354 WP_094873350.1 type II toxin-antitoxin system PemK/MazF family toxin -
CF557_RS05635 (CF557_05635) 1196397..1196684 - 288 WP_013746939.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CF557_RS05640 (CF557_05640) 1196694..1196942 - 249 WP_039087491.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
CF557_RS05645 (CF557_05645) 1197059..1198162 - 1104 WP_094873348.1 porin -
CF557_RS05650 (CF557_05650) 1198928..1199989 + 1062 WP_094873347.1 porin -
CF557_RS05655 (CF557_05655) 1200296..1201426 - 1131 WP_094873345.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-87)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11026.94 Da        Isoelectric Point: 10.4262

>T266448 WP_013746939.1 NZ_CP114281:c1196684-1196397 [Gallibacterium anatis]
MAYAIKVHSDFVAELNKLDSTIKNQLRKKLEKVVHNPHIPKNRLSGELHNCYKIKLRKAGVRLVYQVNDDEIYILLLTVG
KREAKQVYNTALNRV

Download         Length: 288 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9345.69 Da        Isoelectric Point: 4.4230

>AT266448 WP_039087491.1 NZ_CP114281:c1196942-1196694 [Gallibacterium anatis]
MANLNIRIDDTIKQRAFLAFDNLGINPSEAIRTFLTYVADTGRMPIKQIIVSDEDAELYEVVKKRLNEPEKITATTLDEL
FS

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F4HF99

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2ZZB6

References