Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 832525..833147 Replicon chromosome
Accession NZ_CP114281
Organism Gallibacterium anatis strain ESV200

Toxin (Protein)


Gene name hicA Uniprot ID A0A0A2YI69
Locus tag CF557_RS03985 Protein ID WP_039095731.1
Coordinates 832525..832707 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A0A2YMS8
Locus tag CF557_RS03990 Protein ID WP_039095729.1
Coordinates 832737..833147 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CF557_RS03965 (CF557_03965) 830022..831038 + 1017 WP_094873405.1 GTP 3',8-cyclase MoaA -
CF557_RS03970 (CF557_03970) 831061..831543 + 483 WP_013747232.1 cyclic pyranopterin monophosphate synthase MoaC -
CF557_RS03975 (CF557_03975) 831540..831785 + 246 WP_021461514.1 molybdopterin synthase sulfur carrier subunit -
CF557_RS03980 (CF557_03980) 831787..832242 + 456 WP_094873407.1 molybdopterin synthase catalytic subunit MoaE -
CF557_RS03985 (CF557_03985) 832525..832707 + 183 WP_039095731.1 type II toxin-antitoxin system HicA family toxin Toxin
CF557_RS03990 (CF557_03990) 832737..833147 + 411 WP_039095729.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
CF557_RS03995 (CF557_03995) 833440..833757 + 318 Protein_764 KilA-N domain-containing protein -
CF557_RS04000 (CF557_04000) 833846..834289 - 444 WP_018346632.1 terminus macrodomain insulation protein YfbV -
CF557_RS04005 (CF557_04005) 834480..835685 + 1206 WP_094873410.1 acetate kinase -
CF557_RS04010 (CF557_04010) 835752..837890 + 2139 WP_094873413.1 phosphate acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6875.01 Da        Isoelectric Point: 10.5345

>T266447 WP_039095731.1 NZ_CP114281:832525-832707 [Gallibacterium anatis]
VDSKTLIKMIEEDGWIYRNTTGSHRHYTHPIKKGIVTIPHPKKDIKKGTEHSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 15145.22 Da        Isoelectric Point: 4.6295

>AT266447 WP_039095729.1 NZ_CP114281:832737-833147 [Gallibacterium anatis]
MLYPIAIEPGDETHAYGVIVPDIPGCFSAGDTLEEAYANVKDAIVGHLELMVEEGLEIPKPTSIENHRHNPDFTDYGMFF
GVVDVDISHLLGKTERINITMPSYLIKRIDDFVATHPQYKNRSHFLASVSADKIMA

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A2YI69

Antitoxin

Source ID Structure
AlphaFold DB A0A0A2YMS8

References