266443

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3813953..3814577 Replicon chromosome
Accession NZ_CP114280
Organism Dickeya lacustris strain LMG30899

Toxin (Protein)


Gene name Hha Uniprot ID E0SD87
Locus tag O1Q98_RS17255 Protein ID WP_009114000.1
Coordinates 3813953..3814156 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag O1Q98_RS17260 Protein ID WP_125258708.1
Coordinates 3814209..3814577 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q98_RS17225 (O1Q98_17230) 3809579..3809917 + 339 WP_002208627.1 P-II family nitrogen regulator -
O1Q98_RS17230 (O1Q98_17235) 3809961..3811254 + 1294 Protein_3359 ammonium transporter AmtB -
O1Q98_RS17235 (O1Q98_17240) 3811395..3812258 - 864 WP_125258705.1 acyl-CoA thioesterase II -
O1Q98_RS17240 (O1Q98_17245) 3812500..3813057 + 558 WP_125258706.1 YbaY family lipoprotein -
O1Q98_RS17245 (O1Q98_17250) 3813107..3813436 - 330 WP_125258707.1 MGMT family protein -
O1Q98_RS17255 (O1Q98_17260) 3813953..3814156 - 204 WP_009114000.1 HHA domain-containing protein Toxin
O1Q98_RS17260 (O1Q98_17265) 3814209..3814577 - 369 WP_125258708.1 Hha toxicity modulator TomB Antitoxin
O1Q98_RS17265 (O1Q98_17270) 3815060..3815203 - 144 WP_027712817.1 type B 50S ribosomal protein L36 -
O1Q98_RS17270 (O1Q98_17275) 3815219..3815470 - 252 WP_125258709.1 type B 50S ribosomal protein L31 -
O1Q98_RS17275 (O1Q98_17280) 3815628..3818777 - 3150 WP_125258710.1 efflux RND transporter permease subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8133.51 Da        Isoelectric Point: 8.8500

>T266443 WP_009114000.1 NZ_CP114280:c3814156-3813953 [Dickeya lacustris]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFYSAADHRLAELTMNKLYDKVPTAVWKYVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14152.93 Da        Isoelectric Point: 4.8937

>AT266443 WP_125258708.1 NZ_CP114280:c3814577-3814209 [Dickeya lacustris]
MDEYTPQHYDIAQLRFLCENLHDESIATLGDSSHGWVNDPTSAVNLQLNELIDHIAAFIVTYKIKYPHESGLCERVEKYL
DDTYILFSNYGINDAELQKWQKSKSQLFRMFSEKSVCTVVKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X3RNQ0

Antitoxin

Source ID Structure

References