266441

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 3524471..3526323 Replicon chromosome
Accession NZ_CP114280
Organism Dickeya lacustris strain LMG30899

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag O1Q98_RS15875 Protein ID WP_125260435.1
Coordinates 3524471..3525817 (+) Length 449 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag O1Q98_RS15880 Protein ID WP_240632817.1
Coordinates 3525814..3526323 (+) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q98_RS15855 (O1Q98_15860) 3520080..3521587 - 1508 Protein_3088 NCS1 family nucleobase:cation symporter-1 -
O1Q98_RS15860 (O1Q98_15865) 3521753..3522496 + 744 WP_125260438.1 GntR family transcriptional regulator -
O1Q98_RS15865 (O1Q98_15870) 3522493..3523230 + 738 WP_125260437.1 aspartate/glutamate racemase family protein -
O1Q98_RS15870 (O1Q98_15875) 3523274..3524221 + 948 WP_125260436.1 allantoinase PuuE -
O1Q98_RS15875 (O1Q98_15880) 3524471..3525817 + 1347 WP_125260435.1 HipA domain-containing protein Toxin
O1Q98_RS15880 (O1Q98_15885) 3525814..3526323 + 510 WP_240632817.1 helix-turn-helix transcriptional regulator Antitoxin
O1Q98_RS15885 (O1Q98_15890) 3526358..3526741 - 384 WP_125260434.1 oxalurate catabolism protein HpxZ -
O1Q98_RS15890 (O1Q98_15895) 3526748..3528145 - 1398 WP_125260433.1 AtzE family amidohydrolase -
O1Q98_RS15895 (O1Q98_15900) 3528142..3528339 - 198 WP_125260432.1 oxalurate catabolism protein HpxX -
O1Q98_RS15900 (O1Q98_15905) 3528365..3529954 - 1590 WP_125260431.1 gamma-glutamyltransferase family protein -
O1Q98_RS15905 (O1Q98_15910) 3530125..3530964 + 840 WP_125260430.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(165-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(88-143)


Sequences

Toxin        


Download         Length: 449 a.a.        Molecular weight: 50691.33 Da        Isoelectric Point: 4.8992

>T266441 WP_125260435.1 NZ_CP114280:3524471-3525817 [Dickeya lacustris]
MERLTVQAFIDNAWQDIAEIGFPESYRDNYLLTQLDYASDYGIDYMDSDDHHAVSVNYPVRIFFDDGGEPGWMRFLDDII
PAGASRQYWIEHLDLSGLPTQLQDYILLRHATIAPVGHLRIKESIPAQHSGTTRFFSVEDVKNRASDFLDYAQQRGAAAG
GATGAGGEAPKLLLRCNADDEVWIDTWQDDLDCCDTAYLVKFPRGKRSEIDCDILRAEFHYYHELAEMGFDTIPVAGMRL
EEGRHYPSLWLPRFDIEFPGEGRVKRYGMESVYSLLRAGPGSALRHDRTIRTLIAKIAASHMVSVEGKPFDPAAFVIEWV
RRDLLNIAFGNSDNHGRNTAFLRDERGIRLAPIYDFAPMKADPAGIARTTKWPEPLEVGGDYQFERIAQLFSDILSPELL
MATLQQTATQLVGLKARLQRRGVPESIITLPSIGFDYLPEKLQRWGLL

Download         Length: 1347 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 18668.25 Da        Isoelectric Point: 10.8307

>AT266441 WP_240632817.1 NZ_CP114280:3525814-3526323 [Dickeya lacustris]
MSQNRNNNDNHAGEQDIQATIRKLRQRMQERSVAQTYFQPSSVGVATEAADITKVRASKNSRPLNTSERQLAMQNIIRRM
MFGEISQGNTLKELRLNVLGLRQEAYATLVGVSRKTLSEIENGKGNYTADIINKVFKPFGLKVGLMPVSSSLLAEILSTP
ASAGKSDSR

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References