266439

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 2040043..2040570 Replicon chromosome
Accession NZ_CP114280
Organism Dickeya lacustris strain LMG30899

Toxin (Protein)


Gene name relE Uniprot ID D2C2R7
Locus tag O1Q98_RS09245 Protein ID WP_012883161.1
Coordinates 2040043..2040318 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2C2R6
Locus tag O1Q98_RS09250 Protein ID WP_012883160.1
Coordinates 2040322..2040570 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q98_RS09220 (O1Q98_09225) 2035539..2036006 - 468 WP_240632702.1 cyclophilin-like fold protein -
O1Q98_RS09225 (O1Q98_09230) 2036083..2037111 - 1029 WP_125258127.1 alpha/beta hydrolase -
O1Q98_RS09230 (O1Q98_09235) 2037133..2038182 - 1050 WP_125258126.1 NAD(P)-dependent alcohol dehydrogenase -
O1Q98_RS09235 (O1Q98_09240) 2038343..2039260 + 918 WP_125258125.1 LysR family transcriptional regulator -
O1Q98_RS09240 (O1Q98_09245) 2039611..2040006 - 396 WP_125258124.1 DUF6088 family protein -
O1Q98_RS09245 (O1Q98_09250) 2040043..2040318 - 276 WP_012883161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
O1Q98_RS09250 (O1Q98_09255) 2040322..2040570 - 249 WP_012883160.1 ribbon-helix-helix domain-containing protein Antitoxin
O1Q98_RS09255 (O1Q98_09260) 2040681..2041514 - 834 WP_278143540.1 DUF4942 domain-containing protein -
O1Q98_RS09260 (O1Q98_09265) 2041633..2041953 - 321 WP_102802208.1 TA system toxin CbtA family protein -
O1Q98_RS09265 (O1Q98_09270) 2041979..2042380 - 402 WP_240632698.1 type IV toxin-antitoxin system YeeU family antitoxin -
O1Q98_RS09270 (O1Q98_09275) 2042380..2042853 - 474 WP_278143545.1 DNA repair protein RadC -
O1Q98_RS09275 (O1Q98_09280) 2042884..2043705 - 822 WP_278143547.1 DUF932 domain-containing protein -
O1Q98_RS09280 (O1Q98_09285) 2043802..2044668 - 867 WP_033576640.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(9-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 11194.47 Da        Isoelectric Point: 5.1487

>T266439 WP_012883161.1 NZ_CP114280:c2040318-2040043 [Dickeya lacustris]
MEILWTQKAQDDLERIYRFASQYSRQHADDVLDRLFIGTTELVDHPRIGVSQTRYEPREVRKILFDDYEVHYEIQHNTIY
IVDLWHTREDR

Download         Length: 276 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9020.34 Da        Isoelectric Point: 6.4653

>AT266439 WP_012883160.1 NZ_CP114280:c2040570-2040322 [Dickeya lacustris]
MGQPAKQTISAQIPAELAAAVESLAIELDRSKSWVIKEALTAMIEERERQHQRILQGLADVDAGRVVNHADVLDFANKLK
KS

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A375A6K4

Antitoxin

Source ID Structure
AlphaFold DB A0A375A6R5

References