266434

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1140084..1140718 Replicon chromosome
Accession NZ_CP114280
Organism Dickeya lacustris strain LMG30899

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag O1Q98_RS05115 Protein ID WP_125258112.1
Coordinates 1140084..1140488 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag O1Q98_RS05120 Protein ID WP_125258111.1
Coordinates 1140488..1140718 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q98_RS05095 (O1Q98_05090) 1135577..1136002 - 426 WP_125258115.1 glutaredoxin-dependent arsenate reductase -
O1Q98_RS05100 (O1Q98_05095) 1136015..1137304 - 1290 WP_125258114.1 arsenic transporter -
O1Q98_RS05105 (O1Q98_05100) 1137751..1138686 - 936 WP_125258113.1 LysR family transcriptional regulator -
O1Q98_RS05110 (O1Q98_05105) 1138772..1139713 + 942 WP_125258122.1 carbon-nitrogen hydrolase family protein -
O1Q98_RS05115 (O1Q98_05110) 1140084..1140488 - 405 WP_125258112.1 tRNA(fMet)-specific endonuclease VapC Toxin
O1Q98_RS05120 (O1Q98_05115) 1140488..1140718 - 231 WP_125258111.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
O1Q98_RS05125 (O1Q98_05120) 1140812..1141645 - 834 WP_278143107.1 DUF4942 domain-containing protein -
O1Q98_RS05130 (O1Q98_05125) 1141764..1142084 - 321 WP_125258109.1 TA system toxin CbtA family protein -
O1Q98_RS05135 (O1Q98_05130) 1142110..1142510 - 401 Protein_1019 type IV toxin-antitoxin system YeeU family antitoxin -
O1Q98_RS05140 (O1Q98_05135) 1142510..1142983 - 474 WP_278143110.1 DNA repair protein RadC -
O1Q98_RS05145 (O1Q98_05140) 1143014..1143835 - 822 WP_125258105.1 DUF932 domain-containing protein -
O1Q98_RS05150 (O1Q98_05145) 1143933..1144799 - 867 WP_125258104.1 GTPase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-51)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15024.23 Da        Isoelectric Point: 7.9982

>T266434 WP_125258112.1 NZ_CP114280:c1140488-1140084 [Dickeya lacustris]
MLKYLLDTNICIYTIKNKPQEVREAFQRYYGQFAISSITLMELIYGAEKSANPEKNLAVIEGFSARLDIQSYGFDAAVHT
GQIRAELAKQGTPIGPYDAMLAGHARSAGLILITNNVREFERVPGLRVENWVSR

Download         Length: 405 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8674.68 Da        Isoelectric Point: 4.5580

>AT266434 WP_125258111.1 NZ_CP114280:c1140718-1140488 [Dickeya lacustris]
MEKTTVFKSNRSQAVRLPKAVALPDDVRHVDIVAIGRTRIITPAGESWDNWFDEAGVTPDFMSTREQPDEQIRDDF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References