Detailed information of TA system TA266432

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/CC2985(antitoxin)
• Location: 2915404..2915986
• Replicon: chromosome
• Accession: NZ_CP114278
• Organism: Brevundimonas vesicularis strain Br4

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: O2K97_RS14460
• Protein ID: WP_269219805.1
• Coordinates: 2915669..2915986 (+)
• Length: 106 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: -
• Locus tag: O2K97_RS14455
• Protein ID: WP_269219804.1
• Coordinates: 2915404..2915661 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
O2K97_RS14430	2910459..2910719	+	261	WP_269219799.1	Txe/YoeB family addiction module toxin	-
O2K97_RS14435	2910716..2911435	+	720	WP_269219800.1	16S rRNA (uracil(1498)-N(3))-methyltransferase	-
O2K97_RS14440	2911571..2912932	+	1362	WP_269219801.1	glutamate--cysteine ligase	-
O2K97_RS14445	2912929..2913666	-	738	WP_269219802.1	hypothetical protein	-
O2K97_RS14450	2913778..2915349	+	1572	WP_269219803.1	ATP-binding protein	-
O2K97_RS14455	2915404..2915661	+	258	WP_269219804.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
O2K97_RS14460	2915669..2915986	+	318	WP_269219805.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
O2K97_RS14465	2915983..2916732	+	750	WP_269219806.1	DUF72 domain-containing protein	-
O2K97_RS14470	2916808..2917869	+	1062	WP_269219807.1	NAD(P)-dependent alcohol dehydrogenase	-
O2K97_RS14475	2918014..2918739	+	726	WP_066549787.1	acetoacetyl-CoA reductase	-
O2K97_RS14480	2918840..2919556	+	717	WP_269221144.1	DUF4908 domain-containing protein	-
O2K97_RS14485	2919661..2920383	-	723	WP_269219808.1	hydroxyacylglutathione hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-91)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 106 a.a.
• Molecular weight: 11661.27 Da
• Isoelectric Point: 9.3193

>T266432 WP_269219805.1 NZ_CP114278:2915669-2915986 [Brevundimonas vesicularis]
VSARYSNAAKRDLIAIYLDGAAKFGSRQAAAYTTGLGATVRMISDYPLSSRLRTELDLPVRVRTYKAHVIIYVIEEGGVL
VLRFRHGHEDWQSDPLGGDLDKDKP

Nucleotide

• Length: 318 bp

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9510.72 Da
• Isoelectric Point: 4.8481

>AT266432 WP_269219804.1 NZ_CP114278:2915404-2915661 [Brevundimonas vesicularis]
MATMNISLPDPMKAWVEEQAKSGRYANTSDVVRDLIRREQVKAEKIAHWNTLIEEAYASGISEMTFEEIIGEARAEAQAR
ASRAA

Nucleotide

• Length: 258 bp