Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 5425313..5425877 Replicon chromosome
Accession NZ_CP114205
Organism Streptomyces tubercidicus strain DSM 40261

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag STRTU_RS23555 Protein ID WP_159745908.1
Coordinates 5425530..5425877 (+) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag STRTU_RS23550 Protein ID WP_159745906.1
Coordinates 5425313..5425543 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
STRTU_RS23535 (STRTU_004706) 5420339..5421292 + 954 WP_159745900.1 LysR family transcriptional regulator -
STRTU_RS23540 (STRTU_004707) 5421381..5422526 + 1146 WP_159745902.1 allantoicase -
STRTU_RS23545 (STRTU_004708) 5422593..5425187 - 2595 WP_159745904.1 aminopeptidase N -
STRTU_RS23550 (STRTU_004709) 5425313..5425543 + 231 WP_159745906.1 ribbon-helix-helix domain-containing protein Antitoxin
STRTU_RS23555 (STRTU_004710) 5425530..5425877 + 348 WP_159745908.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
STRTU_RS23560 (STRTU_004711) 5425985..5426563 + 579 WP_159745910.1 DUF1203 domain-containing protein -
STRTU_RS23565 (STRTU_004712) 5426630..5427661 - 1032 WP_159745912.1 aspartate-semialdehyde dehydrogenase -
STRTU_RS23570 (STRTU_004713) 5428066..5429805 + 1740 WP_159745914.1 TIGR03767 family metallophosphoesterase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-115)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-38)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12693.64 Da        Isoelectric Point: 10.7701

>T266425 WP_159745908.1 NZ_CP114205:5425530-5425877 [Streptomyces tubercidicus]
MRRGDIYMVDLEPVRGSEASKVRPAVIVSNNGANQSVESNRRGVVTVVPLTSNTSRVLSFQVFLGADECRLPKDSKAQCE
QLRAIALERVLHKVGSVPRQRMAEVDAALRRHLAL

Download         Length: 348 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8389.18 Da        Isoelectric Point: 3.9953

>AT266425 WP_159745906.1 NZ_CP114205:5425313-5425543 [Streptomyces tubercidicus]
MKISVSLPQEDVAFVDEYAARTKGESRSAVIHAAIELLRAAQLESEYTEAFAEWDESKDAALWDRASGDGLADEAW

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References