Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 6227263..6228922 Replicon chromosome
Accession NZ_CP114201
Organism Delftia acidovorans strain BIM B-1761

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag O1V13_RS28285 Protein ID WP_269197679.1
Coordinates 6228092..6228922 (-) Length 277 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID F6ALN8
Locus tag O1V13_RS28280 Protein ID WP_012202883.1
Coordinates 6227263..6228069 (-) Length 269 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1V13_RS28250 (O1V13_28260) 6222691..6223461 - 771 WP_012202888.1 SDR family oxidoreductase -
O1V13_RS28255 (O1V13_28265) 6224273..6224554 + 282 WP_071954164.1 hypothetical protein -
O1V13_RS28260 (O1V13_28270) 6224873..6225220 + 348 WP_013804511.1 type II toxin-antitoxin system RelE/ParE family toxin -
O1V13_RS28265 (O1V13_28275) 6225217..6225525 + 309 WP_269197676.1 Fis family transcriptional regulator -
O1V13_RS28270 (O1V13_28280) 6225538..6226299 - 762 WP_269197677.1 5'-methylthioadenosine/adenosylhomocysteine nucleosidase -
O1V13_RS28275 (O1V13_28285) 6226411..6227208 - 798 WP_269197678.1 aspartate dehydrogenase -
O1V13_RS28280 (O1V13_28290) 6227263..6228069 - 807 WP_012202883.1 IclR family transcriptional regulator Antitoxin
O1V13_RS28285 (O1V13_28295) 6228092..6228922 - 831 WP_269197679.1 alpha/beta fold hydrolase Toxin
O1V13_RS28290 (O1V13_28300) 6229096..6229626 - 531 WP_012202881.1 cupin domain-containing protein -
O1V13_RS28295 (O1V13_28305) 6229809..6231005 - 1197 WP_269199170.1 MFS transporter -
O1V13_RS28300 (O1V13_28310) 6231028..6231912 - 885 WP_016449823.1 NAD(P)-dependent oxidoreductase -
O1V13_RS28305 (O1V13_28315) 6232049..6232639 - 591 WP_013804518.1 TetR/AcrR family transcriptional regulator -
O1V13_RS28310 (O1V13_28320) 6232721..6233212 - 492 WP_269197680.1 Lrp/AsnC family transcriptional regulator -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(35-262)

Antitoxin

(137-255)


Sequences


Toxin        


Download         Length: 277 a.a.        Molecular weight: 28597.75 Da        Isoelectric Point: 7.0403

>T266424 WP_269197679.1 NZ_CP114201:c6228922-6228092 [Delftia acidovorans]
MEQRLQAQFPEHLIALPGGAQAAWREAGDTASDFAVVMLHGISSGAASWLDVALALAPRARVLAWDAPGYGRSTPLAPAA
PTGADYARVLEQSLQALGVRRCLLVGHSLGALMGTPWAVQAGAGRVQQLVLISPAGGYGAPGMGEQQAKVRQGRLAALQE
KGIEGLAAAIDQRLVSPAAPEPVRQWVRWNTARLHAAGYAQAVELLCGSDLGQAAGQLAMPVEVWVGEHDVVTPPAACAA
WAARLGARYVTLAAAGHASVVEQPADVAQRLATLLT

Download         Length: 831 bp


Antitoxin


Download         Length: 269 a.a.        Molecular weight: 29330.45 Da        Isoelectric Point: 5.7085

>AT266424 WP_012202883.1 NZ_CP114201:c6228069-6227263 [Delftia acidovorans]
MSDTSETLSNDNDRYTVPALERGLRLLACFTPSQPVWSAPDLARTLALPRSTVFRMLTTLENMGYLQRSGTEYRLGLSVL
RLGYDYLSTQPLAQLAEPVLQALCERLGFTTNLALLDGTSVVYVARIAPAGAFQGAVRVGSRLPAHATVLGRALLQDMDA
DQLRELFGGSELPQFSESTPRDVQQLQQLLLQDRERGYAMGEGFYEPGVSSIAAPVRDAQGRIIAGLGMAVAFTEIAPGR
MAHWVEQVREAAVELTGHLRTQHPGFLR

Download         Length: 807 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure
AlphaFold DB A0A031HDN8

References