266409

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1256686..1257603 Replicon chromosome
Accession NZ_CP114180
Organism Bacillus velezensis strain DMW1

Toxin (Protein)


Gene name spoIISA Uniprot ID I2HQ15
Locus tag M1L51_RS06445 Protein ID WP_007407256.1
Coordinates 1256857..1257603 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag M1L51_RS06440 Protein ID WP_003154807.1
Coordinates 1256686..1256856 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M1L51_RS06405 1251897..1253486 + 1590 WP_053573489.1 hypothetical protein -
M1L51_RS06410 1253499..1253924 + 426 WP_053573490.1 hypothetical protein -
M1L51_RS06415 1253929..1254126 + 198 WP_012117366.1 XkdX family protein -
M1L51_RS06420 1254183..1254944 + 762 WP_053573491.1 hypothetical protein -
M1L51_RS06425 1254996..1255259 + 264 WP_003154815.1 hemolysin XhlA family protein -
M1L51_RS06430 1255273..1255536 + 264 WP_003154813.1 phage holin -
M1L51_RS06435 1255550..1256428 + 879 WP_007407257.1 N-acetylmuramoyl-L-alanine amidase -
M1L51_RS06440 1256686..1256856 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
M1L51_RS06445 1256857..1257603 - 747 WP_007407256.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
M1L51_RS06450 1257707..1258705 - 999 WP_003154805.1 inorganic phosphate transporter -
M1L51_RS06455 1258718..1259335 - 618 WP_003154804.1 DUF47 domain-containing protein -
M1L51_RS06460 1259621..1260937 - 1317 WP_007610842.1 amino acid permease -
M1L51_RS06465 1261260..1262210 + 951 WP_031378808.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1222155..1265865 43710


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29077.57 Da        Isoelectric Point: 4.7755

>T266409 WP_007407256.1 NZ_CP114180:c1257603-1256857 [Bacillus velezensis]
MLLFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT266409 WP_003154807.1 NZ_CP114180:c1256856-1256686 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I2HQ15

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References