Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4471625..4473219 Replicon chromosome
Accession NZ_CP114168
Organism Klebsiella variicola strain 2022CK-00565

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OIX89_RS21595 Protein ID WP_101827469.1
Coordinates 4471625..4472953 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2V3KHJ7
Locus tag OIX89_RS21600 Protein ID WP_038422544.1
Coordinates 4472953..4473219 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIX89_RS21580 (OIX89_21580) 4467858..4468862 + 1005 WP_032730346.1 fimbrial protein -
OIX89_RS21585 (OIX89_21585) 4468995..4470287 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
OIX89_RS21590 (OIX89_21590) 4470422..4471426 + 1005 WP_000427614.1 IS110-like element IS5075 family transposase -
OIX89_RS21595 (OIX89_21595) 4471625..4472953 - 1329 WP_101827469.1 type II toxin-antitoxin system HipA family toxin Toxin
OIX89_RS21600 (OIX89_21600) 4472953..4473219 - 267 WP_038422544.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OIX89_RS21605 (OIX89_21605) 4473485..4473811 - 327 WP_008804921.1 hydroxyisourate hydrolase -
OIX89_RS21610 (OIX89_21610) 4473808..4474308 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OIX89_RS21615 (OIX89_21615) 4474286..4475665 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
OIX89_RS21620 (OIX89_21620) 4476011..4477165 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
OIX89_RS21625 (OIX89_21625) 4477146..4478069 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 4470422..4471426 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48997.39 Da        Isoelectric Point: 7.2497

>T266402 WP_101827469.1 NZ_CP114168:c4472953-4471625 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGELMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITESMVTPVFATPILTTSWLA

Download         Length: 1329 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9923.30 Da        Isoelectric Point: 8.5912

>AT266402 WP_038422544.1 NZ_CP114168:c4473219-4472953 [Klebsiella variicola]
MTSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3KHJ7

References