Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 2423670..2424327 Replicon chromosome
Accession NZ_CP114168
Organism Klebsiella variicola strain 2022CK-00565

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag OIX89_RS11635 Protein ID WP_002916310.1
Coordinates 2423917..2424327 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag OIX89_RS11630 Protein ID WP_002916312.1
Coordinates 2423670..2423936 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIX89_RS11605 (OIX89_11605) 2420112..2420840 - 729 WP_012967245.1 MurR/RpiR family transcriptional regulator -
OIX89_RS11610 (OIX89_11610) 2420891..2421202 + 312 WP_015369789.1 N(4)-acetylcytidine aminohydrolase -
OIX89_RS11615 (OIX89_11615) 2421366..2422025 + 660 WP_008806429.1 hemolysin III family protein -
OIX89_RS11620 (OIX89_11620) 2422056..2422394 + 339 WP_145940792.1 hypothetical protein -
OIX89_RS11625 (OIX89_11625) 2422441..2423424 - 984 WP_023340714.1 tRNA-modifying protein YgfZ -
OIX89_RS11630 (OIX89_11630) 2423670..2423936 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
OIX89_RS11635 (OIX89_11635) 2423917..2424327 + 411 WP_002916310.1 protein YgfX Toxin
OIX89_RS11640 (OIX89_11640) 2424334..2424855 - 522 WP_008806427.1 flavodoxin FldB -
OIX89_RS11645 (OIX89_11645) 2424956..2425852 + 897 WP_008806426.1 site-specific tyrosine recombinase XerD -
OIX89_RS11650 (OIX89_11650) 2425875..2426588 + 714 WP_012540593.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OIX89_RS11655 (OIX89_11655) 2426594..2428327 + 1734 WP_032736401.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T266394 WP_002916310.1 NZ_CP114168:2423917-2424327 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT266394 WP_002916312.1 NZ_CP114168:2423670-2423936 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References