Detailed information of TA system TA026639

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TscAT/-
• Location: 908921..909426
• Replicon: chromosome
• Accession: NC_017341
• Organism: Staphylococcus aureus subsp. aureus str. JKD6008

Toxin (Protein)

• Gene name: TscT
• Uniprot ID: A0A0C6E6D5
• Locus tag: SAA6008_RS04490
• Protein ID: WP_001103946.1
• Coordinates: 909133..909426 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: TscA
• Uniprot ID: X5IA75
• Locus tag: SAA6008_RS04485
• Protein ID: WP_001058492.1
• Coordinates: 908921..909130 (+)
• Length: 70 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SAA6008_RS04450	904438..905658	-	1221	WP_000264182.1	site-specific integrase	-
SAA6008_RS04455	905746..906474	-	729	WP_000733773.1	staphylococcal enterotoxin type K	-
SAA6008_RS04460	906498..907226	-	729	WP_001033317.1	staphylococcal enterotoxin type Q	-
SAA6008_RS04465	907401..908135	-	735	WP_000142630.1	helix-turn-helix domain-containing protein	-
SAA6008_RS04470	908285..908497	+	213	WP_001063624.1	helix-turn-helix transcriptional regulator	-
SAA6008_RS04475	908498..908770	+	273	WP_001138298.1	helix-turn-helix domain-containing protein	-
SAA6008_RS04480	908782..908928	+	147	WP_000784885.1	hypothetical protein	-
SAA6008_RS04485	908921..909130	+	210	WP_001058492.1	hypothetical protein	Antitoxin
SAA6008_RS04490	909133..909426	+	294	WP_001103946.1	DUF1474 family protein	Toxin
SAA6008_RS04495	909514..910383	+	870	WP_001002692.1	primase alpha helix C-terminal domain-containing protein	-
SAA6008_RS04500	910400..911857	+	1458	WP_000432707.1	virulence-associated E family protein	-
SAA6008_RS04505	912159..912521	+	363	WP_001039172.1	hypothetical protein	-
SAA6008_RS04510	912523..912807	+	285	WP_000998180.1	hypothetical protein	-
SAA6008_RS04515	912804..913445	+	642	WP_001019783.1	hypothetical protein	-
SAA6008_RS04520	913872..914234	+	363	WP_041174166.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	ant(9)-Ia / erm(A)	selk / selq	879801..916548	36747

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-97)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 11590.08 Da
• Isoelectric Point: 4.9594

>T26639 WP_001103946.1 NC_017341:909133-909426 [Staphylococcus aureus subsp. aureus str. JKD6008]
MNWEIKDLMCDIEVIKQKINDVATKHAWFVEDRFVKNELETKREHINFSASYLEHRIQNEHTVELLQVYLKEFGELIQKF
HEIEKASLQADQSESNA

Nucleotide

• Length: 294 bp

>T26639 NC_017341:909133-909426 [Staphylococcus aureus subsp. aureus str. JKD6008]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACAAGTGTACTTAAAAGAGTTCGGTGAACTTATACAAAAGTTT
CATGAAATAGAAAAAGCGTCACTTCAAGCCGACCAAAGCGAAAGTAACGCATAG

Antitoxin

Protein

• Length: 70 a.a.
• Molecular weight: 8238.28 Da
• Isoelectric Point: 4.3718

>AT26639 WP_001058492.1 NC_017341:908921-909130 [Staphylococcus aureus subsp. aureus str. JKD6008]
MNNEQKEVIEHVVYQLELSVMNNLESYEHTEYVNGIEVVSEISREKHLELIMKWCAQELKNNFQLEKGE

Nucleotide

• Length: 210 bp

>AT26639 NC_017341:908921-909130 [Staphylococcus aureus subsp. aureus str. JKD6008]
ATGAATAATGAACAAAAAGAAGTAATAGAACACGTGGTTTATCAACTTGAGTTAAGTGTCATGAATAACTTGGAAAGTTA
TGAACACACAGAATATGTTAATGGTATTGAAGTGGTTTCAGAGATCAGTCGTGAAAAGCACTTAGAATTGATAATGAAAT
GGTGCGCACAAGAATTAAAGAATAATTTTCAATTAGAGAAAGGAGAATAA

Structures

Toxin

• AlphaFold DB: A0A0C6E6D5

Antitoxin

• AlphaFold DB: X5IA75