Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 1230467..1232148 Replicon chromosome
Accession NZ_CP114168
Organism Klebsiella variicola strain 2022CK-00565

Toxin (Protein)


Gene name mosT Uniprot ID A0A1F2M1V2
Locus tag OIX89_RS05880 Protein ID WP_032734038.1
Coordinates 1230467..1231384 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID -
Locus tag OIX89_RS05885 Protein ID WP_110242892.1
Coordinates 1231390..1232148 (-) Length 253 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIX89_RS05860 (OIX89_05860) 1225773..1227293 + 1521 WP_110242893.1 sugar ABC transporter ATP-binding protein -
OIX89_RS05865 (OIX89_05865) 1227290..1228288 + 999 WP_023296904.1 ribose ABC transporter permease -
OIX89_RS05870 (OIX89_05870) 1228319..1229260 + 942 WP_012543155.1 ABC transporter substrate-binding protein -
OIX89_RS05875 (OIX89_05875) 1229335..1230342 + 1008 WP_022065799.1 carbohydrate kinase family protein -
OIX89_RS05880 (OIX89_05880) 1230467..1231384 - 918 WP_032734038.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
OIX89_RS05885 (OIX89_05885) 1231390..1232148 - 759 WP_110242892.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
OIX89_RS05890 (OIX89_05890) 1232233..1232961 - 729 WP_008807258.1 response regulator transcription factor -
OIX89_RS05895 (OIX89_05895) 1233234..1235381 + 2148 WP_077625453.1 formate dehydrogenase subunit alpha -
OIX89_RS05900 (OIX89_05900) 1235735..1236421 + 687 WP_008807260.1 tetratricopeptide repeat protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.



Sequences


Toxin        


Download         Length: 306 a.a.        Molecular weight: 34733.10 Da        Isoelectric Point: 5.4707

>T266389 WP_032734038.1 NZ_CP114168:c1231384-1230467 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRTIALPHIRDALARIAANLQQQ
AGINAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp


Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28657.94 Da        Isoelectric Point: 10.1988

>AT266389 WP_110242892.1 NZ_CP114168:c1232148-1231390 [Klebsiella variicola]
MSSKLNWLLQNSAPGDVILQSWLSRHAISPSQAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A1F2M1V2


Antitoxin

Source ID Structure

References