Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2845434..2847028 Replicon chromosome
Accession NZ_CP114164
Organism Klebsiella variicola strain 2022CK-00564

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OIX91_RS13885 Protein ID WP_101827469.1
Coordinates 2845434..2846762 (-) Length 443 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2V3KHJ7
Locus tag OIX91_RS13890 Protein ID WP_038422544.1
Coordinates 2846762..2847028 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIX91_RS13870 (OIX91_13870) 2841667..2842671 + 1005 WP_032730346.1 fimbrial protein -
OIX91_RS13875 (OIX91_13875) 2842804..2844096 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
OIX91_RS13880 (OIX91_13880) 2844231..2845235 + 1005 WP_000427614.1 IS110-like element IS5075 family transposase -
OIX91_RS13885 (OIX91_13885) 2845434..2846762 - 1329 WP_101827469.1 type II toxin-antitoxin system HipA family toxin Toxin
OIX91_RS13890 (OIX91_13890) 2846762..2847028 - 267 WP_038422544.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
OIX91_RS13895 (OIX91_13895) 2847294..2847620 - 327 WP_008804921.1 hydroxyisourate hydrolase -
OIX91_RS13900 (OIX91_13900) 2847617..2848117 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
OIX91_RS13905 (OIX91_13905) 2848095..2849474 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
OIX91_RS13910 (OIX91_13910) 2849820..2850974 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
OIX91_RS13915 (OIX91_13915) 2850955..2851878 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2844231..2845235 1004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 443 a.a.        Molecular weight: 48997.39 Da        Isoelectric Point: 7.2497

>T266379 WP_101827469.1 NZ_CP114164:c2846762-2845434 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGELMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITESMVTPVFATPILTTSWLA

Download         Length: 1329 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9923.30 Da        Isoelectric Point: 8.5912

>AT266379 WP_038422544.1 NZ_CP114164:c2847028-2846762 [Klebsiella variicola]
MTSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2V3KHJ7

References