Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1722998..1723995 Replicon chromosome
Accession NZ_CP114164
Organism Klebsiella variicola strain 2022CK-00564

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag OIX91_RS08405 Protein ID WP_229531768.1
Coordinates 1723441..1723995 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag OIX91_RS08400 Protein ID WP_012541033.1
Coordinates 1722998..1723444 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OIX91_RS08385 (OIX91_08385) 1719293..1720291 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
OIX91_RS08390 (OIX91_08390) 1720410..1721930 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
OIX91_RS08395 (OIX91_08395) 1721946..1722956 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
OIX91_RS08400 (OIX91_08400) 1722998..1723444 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
OIX91_RS08405 (OIX91_08405) 1723441..1723995 - 555 WP_229531768.1 HipA domain-containing protein Toxin
OIX91_RS08410 (OIX91_08410) 1724024..1724545 - 522 WP_025714688.1 hypothetical protein -
OIX91_RS08415 (OIX91_08415) 1724660..1725391 - 732 WP_008804033.1 outer membrane permeability protein SanA -
OIX91_RS08420 (OIX91_08420) 1725684..1726568 - 885 WP_262266825.1 cytidine deaminase -
OIX91_RS08425 (OIX91_08425) 1726697..1727392 - 696 WP_061153873.1 CidB/LrgB family autolysis modulator -
OIX91_RS08430 (OIX91_08430) 1727382..1727786 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20710.03 Da        Isoelectric Point: 5.7891

>T266372 WP_229531768.1 NZ_CP114164:c1723995-1723441 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT266372 WP_012541033.1 NZ_CP114164:c1723444-1722998 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References