Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4821122..4821593 Replicon chromosome
Accession NZ_CP114160
Organism Klebsiella quasipneumoniae strain 2022CK-00516

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag N5B28_RS23225 Protein ID WP_023291758.1
Coordinates 4821122..4821361 (-) Length 80 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1C1EW86
Locus tag N5B28_RS23230 Protein ID WP_023291757.1
Coordinates 4821351..4821593 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5B28_RS23215 (4818075) 4818075..4820213 + 2139 WP_004206513.1 anaerobic ribonucleoside-triphosphate reductase -
N5B28_RS23220 (4820609) 4820609..4821073 + 465 WP_012969085.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
N5B28_RS23225 (4821122) 4821122..4821361 - 240 WP_023291758.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N5B28_RS23230 (4821351) 4821351..4821593 - 243 WP_023291757.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
N5B28_RS23235 (4821671) 4821671..4823581 - 1911 WP_264980305.1 BglG family transcription antiterminator -
N5B28_RS23240 (4823604) 4823604..4824758 - 1155 WP_264980307.1 lactonase family protein -
N5B28_RS23245 (4824825) 4824825..4825565 - 741 WP_269135527.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-79)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 80 a.a.        Molecular weight: 9162.72 Da        Isoelectric Point: 10.1315

>T266363 WP_023291758.1 NZ_CP114160:c4821361-4821122 [Klebsiella quasipneumoniae]
MTYELAFDPRAWREWQKLGETIKKQFKNKLQQVVQNPRIASASLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIG

Download         Length: 240 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9119.58 Da        Isoelectric Point: 4.8146

>AT266363 WP_023291757.1 NZ_CP114160:c4821593-4821351 [Klebsiella quasipneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDSEAALLRTVRERLENPQPEVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1C1EW86

References