Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2719465..2721053 Replicon chromosome
Accession NZ_CP114160
Organism Klebsiella quasipneumoniae strain 2022CK-00516

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag N5B28_RS13255 Protein ID WP_269134983.1
Coordinates 2719465..2720787 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A2N4W0X3
Locus tag N5B28_RS13260 Protein ID WP_023289667.1
Coordinates 2720787..2721053 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N5B28_RS13240 (2714521) 2714521..2717022 + 2502 WP_269134982.1 fimbria/pilus outer membrane usher protein -
N5B28_RS13245 (2717010) 2717010..2718014 + 1005 WP_044523017.1 fimbrial protein -
N5B28_RS13250 (2718156) 2718156..2719448 + 1293 WP_044523014.1 glycoside hydrolase family 10 protein -
N5B28_RS13255 (2719465) 2719465..2720787 - 1323 WP_269134983.1 type II toxin-antitoxin system HipA family toxin Toxin
N5B28_RS13260 (2720787) 2720787..2721053 - 267 WP_023289667.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
N5B28_RS13265 (2721440) 2721440..2721766 - 327 WP_269134984.1 hydroxyisourate hydrolase -
N5B28_RS13270 (2721763) 2721763..2722263 - 501 WP_032452825.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
N5B28_RS13275 (2722241) 2722241..2723620 - 1380 WP_032452824.1 nucleobase:cation symporter-2 family protein -
N5B28_RS13280 (2723966) 2723966..2725120 + 1155 WP_064154633.1 FAD-dependent urate hydroxylase HpxO -
N5B28_RS13285 (2725101) 2725101..2726024 - 924 WP_023289662.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49237.58 Da        Isoelectric Point: 8.8996

>T266361 WP_269134983.1 NZ_CP114160:c2720787-2719465 [Klebsiella quasipneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDDEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAYLAALRWQTLDEAQLTALLTAYQSDIPLGMVTGQDDFRISVAGAQEKTAL
LRMGEHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARALGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATRGRKTEINAIYPRHFLATAKAVNFPRDQMLAILDEFADRVP
QAIESARRTLPADFSAHVWRAITENMLKLHARLRQGLQAR

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9891.25 Da        Isoelectric Point: 7.3163

>AT266361 WP_023289667.1 NZ_CP114160:c2721053-2720787 [Klebsiella quasipneumoniae]
MHSPQIYSPVQLANYLKLLRQQNHWTQEALASRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKPAETATAP
DNTTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2N4W0X3

References