Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 17328..18064 Replicon plasmid unnamed1
Accession NZ_CP114157
Organism Klebsiella michiganensis strain 2022CK-00497

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag OEE44_RS28030 Protein ID WP_060589645.1
Coordinates 17328..17810 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OEE44_RS28035 Protein ID WP_032415032.1
Coordinates 17798..18064 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE44_RS28005 (OEE44_28005) 12823..13248 - 426 WP_000065802.1 glutaredoxin-dependent arsenate reductase -
OEE44_RS28010 (OEE44_28010) 13261..14550 - 1290 WP_000922628.1 arsenic transporter -
OEE44_RS28015 (OEE44_28015) 14596..14916 - 321 WP_000941305.1 transcriptional regulator -
OEE44_RS28020 (OEE44_28020) 15003..15707 + 705 WP_062939642.1 arsenical resistance protein ArsH -
OEE44_RS28025 (OEE44_28025) 15740..17143 - 1404 WP_060589555.1 ISNCY family transposase -
OEE44_RS28030 (OEE44_28030) 17328..17810 - 483 WP_060589645.1 GNAT family N-acetyltransferase Toxin
OEE44_RS28035 (OEE44_28035) 17798..18064 - 267 WP_032415032.1 DUF1778 domain-containing protein Antitoxin
OEE44_RS28040 (OEE44_28040) 18240..18494 - 255 WP_060589646.1 hypothetical protein -
OEE44_RS28045 (OEE44_28045) 18898..19734 - 837 WP_060589647.1 EAL domain-containing protein -
OEE44_RS28050 (OEE44_28050) 19750..20478 - 729 Protein_25 CSS-motif domain-containing protein -
OEE44_RS28055 (OEE44_28055) 20956..21213 + 258 WP_086074090.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..173797 173797
- inside IScluster/Tn - - 15740..30440 14700


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(66-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17339.05 Da        Isoelectric Point: 10.0704

>T266352 WP_060589645.1 NZ_CP114157:c17810-17328 [Klebsiella michiganensis]
VGRITAPEPLSSAHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKKGTKKVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLT

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10123.53 Da        Isoelectric Point: 4.5141

>AT266352 WP_032415032.1 NZ_CP114157:c18064-17798 [Klebsiella michiganensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDEQYAEFIDMLDAPVEDDSAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References