Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 871201..871858 Replicon chromosome
Accession NZ_CP114156
Organism Klebsiella michiganensis strain 2022CK-00497

Toxin (Protein)


Gene name cptA Uniprot ID J5U333
Locus tag OEE44_RS04210 Protein ID WP_004854060.1
Coordinates 871448..871858 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag OEE44_RS04205 Protein ID WP_004124953.1
Coordinates 871201..871467 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE44_RS04190 (OEE44_04190) 866435..866860 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
OEE44_RS04195 (OEE44_04195) 866981..869779 - 2799 WP_049079129.1 transcriptional regulator DagR -
OEE44_RS04200 (OEE44_04200) 869973..870956 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
OEE44_RS04205 (OEE44_04205) 871201..871467 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
OEE44_RS04210 (OEE44_04210) 871448..871858 + 411 WP_004854060.1 protein YgfX Toxin
OEE44_RS04215 (OEE44_04215) 871867..872388 - 522 WP_143440241.1 flavodoxin FldB -
OEE44_RS04220 (OEE44_04220) 872510..873406 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
OEE44_RS04225 (OEE44_04225) 873429..874142 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEE44_RS04230 (OEE44_04230) 874148..875881 + 1734 WP_182095148.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16106.97 Da        Isoelectric Point: 10.9455

>T266344 WP_004854060.1 NZ_CP114156:871448-871858 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDAGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT266344 WP_004124953.1 NZ_CP114156:871201-871467 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GYA5

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References