Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 772837..773615 Replicon chromosome
Accession NZ_CP114156
Organism Klebsiella michiganensis strain 2022CK-00497

Toxin (Protein)


Gene name TacT2 Uniprot ID -
Locus tag OEE44_RS03715 Protein ID WP_182094790.1
Coordinates 773127..773615 (+) Length 163 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A2J5Q8I3
Locus tag OEE44_RS03710 Protein ID WP_049101739.1
Coordinates 772837..773130 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE44_RS03690 (OEE44_03690) 767993..769138 - 1146 WP_085520127.1 PLP-dependent aspartate aminotransferase family protein -
OEE44_RS03695 (OEE44_03695) 769149..770519 - 1371 WP_025105933.1 cystathionine beta-synthase -
OEE44_RS03700 (OEE44_03700) 770553..770795 + 243 WP_014226848.1 hypothetical protein -
OEE44_RS03705 (OEE44_03705) 771065..772453 + 1389 WP_048260433.1 DASS family sodium-coupled anion symporter -
OEE44_RS03710 (OEE44_03710) 772837..773130 + 294 WP_049101739.1 DUF1778 domain-containing protein Antitoxin
OEE44_RS03715 (OEE44_03715) 773127..773615 + 489 WP_182094790.1 GNAT family N-acetyltransferase Toxin
OEE44_RS03720 (OEE44_03720) 773680..774378 + 699 WP_032692862.1 hypothetical protein -
OEE44_RS03725 (OEE44_03725) 774485..776185 - 1701 WP_032692861.1 hypothetical protein -
OEE44_RS03730 (OEE44_03730) 776182..778092 - 1911 WP_182094789.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-143)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17731.67 Da        Isoelectric Point: 7.7536

>T266343 WP_182094790.1 NZ_CP114156:773127-773615 [Klebsiella michiganensis]
MISTPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQLSGASRTFVCCHDAKVMAYYSLASSAVTTNTAPGRFRRNMPDPI
PVVVLGRLAVDRSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMMFMVTLGDLVE
SI

Download         Length: 489 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10902.55 Da        Isoelectric Point: 9.8590

>AT266343 WP_049101739.1 NZ_CP114156:772837-773130 [Klebsiella michiganensis]
MPAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQAPAPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J5Q8I3

References