Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | ccdAB/CcdA(antitoxin) |
Location | 5824..6349 | Replicon | plasmid unnamed2 |
Accession | NZ_CP114151 | ||
Organism | Klebsiella michiganensis strain 2022CK-00496 |
Toxin (Protein)
Gene name | ccdB | Uniprot ID | D4HQE7 |
Locus tag | OEE45_RS29065 | Protein ID | WP_013023785.1 |
Coordinates | 5824..6129 (-) | Length | 102 a.a. |
Antitoxin (Protein)
Gene name | ccdA | Uniprot ID | W8V2V6 |
Locus tag | OEE45_RS29070 | Protein ID | WP_001568025.1 |
Coordinates | 6131..6349 (-) | Length | 73 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OEE45_RS29035 (OEE45_29045) | 1511..2137 | + | 627 | WP_004197649.1 | ParA family plasmid-partitioning AAA ATPase | - |
OEE45_RS29040 (OEE45_29050) | 2134..2436 | + | 303 | WP_004197636.1 | hypothetical protein | - |
OEE45_RS29045 (OEE45_29055) | 2900..3694 | - | 795 | WP_053389905.1 | site-specific integrase | - |
OEE45_RS29050 (OEE45_29060) | 3892..4908 | - | 1017 | WP_017899884.1 | hypothetical protein | - |
OEE45_RS29055 (OEE45_29065) | 4919..5233 | - | 315 | WP_053389906.1 | hypothetical protein | - |
OEE45_RS29060 (OEE45_29070) | 5260..5655 | - | 396 | WP_162269742.1 | hypothetical protein | - |
OEE45_RS29065 (OEE45_29075) | 5824..6129 | - | 306 | WP_013023785.1 | type II toxin-antitoxin system toxin CcdB | Toxin |
OEE45_RS29070 (OEE45_29080) | 6131..6349 | - | 219 | WP_001568025.1 | type II toxin-antitoxin system antitoxin CcdA | Antitoxin |
OEE45_RS29075 (OEE45_29085) | 6519..6764 | - | 246 | Protein_9 | hypothetical protein | - |
OEE45_RS29080 (OEE45_29090) | 6914..7426 | + | 513 | WP_117326276.1 | hypothetical protein | - |
OEE45_RS29085 (OEE45_29095) | 7460..8593 | - | 1134 | WP_000545987.1 | DUF3800 domain-containing protein | - |
OEE45_RS29090 (OEE45_29100) | 8760..9533 | - | 774 | WP_270038079.1 | hypothetical protein | - |
OEE45_RS29095 (OEE45_29105) | 9546..10046 | - | 501 | WP_116967875.1 | HEPN family nuclease | - |
OEE45_RS29100 (OEE45_29110) | 10321..10584 | + | 264 | WP_043519726.1 | hypothetical protein | - |
OEE45_RS29105 (OEE45_29115) | 10581..11147 | + | 567 | WP_202707995.1 | hypothetical protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | aadA2 / qacE / sul1 | - | 1..131529 | 131529 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11615.30 Da Isoelectric Point: 6.4672
>T266341 WP_013023785.1 NZ_CP114151:c6129-5824 [Klebsiella michiganensis]
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
MQFKVYAYKRESRYRLFVDVQSDIIDTPGRRMVIPLASARLLSDKVSRELYPVVHIGDESYRLMTTDMASVTSSVTGEEV
ADLSHRENDIKNAINLMFWGI
Download Length: 306 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZW6 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A2J4ZZP8 |