Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 72721..73457 Replicon plasmid unnamed1
Accession NZ_CP114150
Organism Klebsiella michiganensis strain 2022CK-00496

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag OEE45_RS28465 Protein ID WP_181479570.1
Coordinates 72721..73203 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag OEE45_RS28470 Protein ID WP_049083184.1
Coordinates 73191..73457 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE45_RS28445 (OEE45_28455) 67771..68421 - 651 Protein_81 helix-turn-helix domain-containing protein -
OEE45_RS28450 (OEE45_28460) 68698..69402 - 705 WP_031591821.1 toll/interleukin-1 receptor domain-containing protein -
OEE45_RS28455 (OEE45_28465) 69562..70908 - 1347 WP_077251107.1 ISNCY family transposase -
OEE45_RS28460 (OEE45_28470) 71031..72563 + 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -
OEE45_RS28465 (OEE45_28475) 72721..73203 - 483 WP_181479570.1 GNAT family N-acetyltransferase Toxin
OEE45_RS28470 (OEE45_28480) 73191..73457 - 267 WP_049083184.1 DUF1778 domain-containing protein Antitoxin
OEE45_RS28475 (OEE45_28485) 73553..73876 + 324 WP_115656969.1 hypothetical protein -
OEE45_RS28480 (OEE45_28490) 73929..74710 - 782 Protein_88 IS21-like element ISSen3 family helper ATPase IstB -
OEE45_RS28485 (OEE45_28495) 74707..75729 - 1023 WP_110184588.1 IS21 family transposase -
OEE45_RS28490 (OEE45_28500) 75819..76283 + 465 WP_177957707.1 hypothetical protein -
OEE45_RS28500 (OEE45_28510) 77190..78158 - 969 WP_270037960.1 IS5 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..186939 186939
- inside IScluster/Tn - - 63548..78158 14610


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(45-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17354.96 Da        Isoelectric Point: 9.1188

>T266340 WP_181479570.1 NZ_CP114150:c73203-72721 [Klebsiella michiganensis]
VGRITAPEPLSSSHQLAEFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVVENIGVRAIMVHALTEEAKGFYTHHGFTASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10117.61 Da        Isoelectric Point: 4.6437

>AT266340 WP_049083184.1 NZ_CP114150:c73457-73191 [Klebsiella michiganensis]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDVQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References