266339

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 38315..38837 Replicon plasmid unnamed1
Accession NZ_CP114150
Organism Klebsiella michiganensis strain 2022CK-00496

Toxin (Protein)


Gene name stbE Uniprot ID A0A9J6S4Z8
Locus tag OEE45_RS28280 Protein ID WP_004187019.1
Coordinates 38315..38599 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A2J4ZSR4
Locus tag OEE45_RS28285 Protein ID WP_004187025.1
Coordinates 38589..38837 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE45_RS28260 (OEE45_28270) 33338..34627 + 1290 WP_115656965.1 arsenite efflux transporter membrane subunit ArsB -
OEE45_RS28265 (OEE45_28275) 34640..35068 + 429 WP_035897523.1 glutaredoxin-dependent arsenate reductase -
OEE45_RS28270 (OEE45_28280) 35335..36867 - 1533 WP_009310015.1 IS3-like element ISKpn38 family transposase -
OEE45_RS28275 (OEE45_28285) 36956..38299 + 1344 WP_040120121.1 ISNCY family transposase -
OEE45_RS28280 (OEE45_28290) 38315..38599 - 285 WP_004187019.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
OEE45_RS28285 (OEE45_28295) 38589..38837 - 249 WP_004187025.1 plasmid stabilization protein Antitoxin
OEE45_RS28290 (OEE45_28300) 39346..40314 - 969 WP_014839948.1 IS5 family transposase -
OEE45_RS28295 (OEE45_28305) 40349..40621 + 273 Protein_51 transposase domain-containing protein -
OEE45_RS28300 (OEE45_28310) 40743..42476 - 1734 WP_032738458.1 nitrilase-related carbon-nitrogen hydrolase -
OEE45_RS28305 (OEE45_28315) 42527..43168 - 642 WP_032430981.1 ANTAR domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - pla 1..186939 186939
- inside IScluster/Tn - - 27976..40621 12645


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11003.72 Da        Isoelectric Point: 10.5388

>T266339 WP_004187019.1 NZ_CP114150:c38599-38315 [Klebsiella michiganensis]
MTYKLAFNESALKEWKKLGHTLQVQFKKKLKERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYRVEDDIVTVTVIGVGK
RENDDIYNATLNRN

Download         Length: 285 bp

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9011.24 Da        Isoelectric Point: 3.9947

>AT266339 WP_004187025.1 NZ_CP114150:c38837-38589 [Klebsiella michiganensis]
MAFQVLTTTAASITELKRDPMGTFHAGDGAPVAILNRNEPAFYCVPPALYAQLMELLEDEELGRMADERSGEKVIEVNID
DL

Download         Length: 249 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A2J4ZSR4

References