Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | /RES-TIGR02293 |
Location | 25384..26294 | Replicon | plasmid unnamed1 |
Accession | NZ_CP114150 | ||
Organism | Klebsiella michiganensis strain 2022CK-00496 |
Toxin (Protein)
Gene name | - | Uniprot ID | A0A2A5MBW7 |
Locus tag | OEE45_RS28210 | Protein ID | WP_023329005.1 |
Coordinates | 25824..26294 (+) | Length | 157 a.a. |
Antitoxin (Protein)
Gene name | - | Uniprot ID | - |
Locus tag | OEE45_RS28205 | Protein ID | WP_110184558.1 |
Coordinates | 25384..25827 (+) | Length | 148 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
OEE45_RS28180 (OEE45_28190) | 21276..21506 | - | 231 | Protein_28 | hypothetical protein | - |
OEE45_RS28185 (OEE45_28195) | 21705..22426 | + | 722 | Protein_29 | DUF969 domain-containing protein | - |
OEE45_RS28190 (OEE45_28200) | 22423..23409 | + | 987 | Protein_30 | DUF979 domain-containing protein | - |
OEE45_RS28195 (OEE45_28205) | 23419..24414 | + | 996 | WP_049084154.1 | DUF2891 domain-containing protein | - |
OEE45_RS28200 (OEE45_28210) | 24596..25262 | + | 667 | Protein_32 | DUF4113 domain-containing protein | - |
OEE45_RS28205 (OEE45_28215) | 25384..25827 | + | 444 | WP_110184558.1 | DUF2384 domain-containing protein | Antitoxin |
OEE45_RS28210 (OEE45_28220) | 25824..26294 | + | 471 | WP_023329005.1 | RES family NAD+ phosphorylase | Toxin |
OEE45_RS28215 (OEE45_28225) | 26476..26664 | - | 189 | WP_023329006.1 | hypothetical protein | - |
OEE45_RS28220 (OEE45_28230) | 27359..28734 | + | 1376 | Protein_36 | IS3 family transposase | - |
OEE45_RS28225 (OEE45_28235) | 28983..29558 | - | 576 | WP_110184559.1 | cytochrome b/b6 domain-containing protein | - |
OEE45_RS28230 (OEE45_28240) | 29706..30011 | + | 306 | WP_023328906.1 | metalloregulator ArsR/SmtB family transcription factor | - |
OEE45_RS28235 (OEE45_28245) | 30013..30529 | + | 517 | Protein_39 | rhodanese-like domain-containing protein | - |
OEE45_RS28240 (OEE45_28250) | 30722..30871 | - | 150 | Protein_40 | cation-efflux pump | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Non-Mobilizable plasmid | - | pla | 1..186939 | 186939 | |
- | inside | IScluster/Tn | - | - | 27976..40621 | 12645 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17459.70 Da Isoelectric Point: 4.4829
>T266338 WP_023329005.1 NZ_CP114150:25824-26294 [Klebsiella michiganensis]
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK
VILYRLTKTKNLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPANWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHSDFYGIVQMAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16461.82 Da Isoelectric Point: 10.2498
>AT266338 WP_110184558.1 NZ_CP114150:25384-25827 [Klebsiella michiganensis]
MKTFSLSSTPARPQRLWQIAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQIAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAALKWLNEPNRALSWKVPADLIASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|