Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-ArgA
Location 4805614..4806433 Replicon chromosome
Accession NZ_CP114149
Organism Klebsiella michiganensis strain 2022CK-00496

Toxin (Protein)


Gene name yjhX Uniprot ID J5WT09
Locus tag OEE45_RS22730 Protein ID WP_004110819.1
Coordinates 4806176..4806433 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID -
Locus tag OEE45_RS22725 Protein ID WP_064405206.1
Coordinates 4805614..4806165 (-) Length 184 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE45_RS22705 (OEE45_22715) 4801836..4802744 - 909 WP_064405202.1 transcriptional regulator GcvA -
OEE45_RS22710 (OEE45_22720) 4802864..4803751 + 888 WP_064405204.1 DMT family transporter -
OEE45_RS22715 (OEE45_22725) 4803968..4804714 - 747 WP_224244006.1 class I SAM-dependent methyltransferase -
OEE45_RS22720 (OEE45_22730) 4805138..4805500 - 363 Protein_4471 class I SAM-dependent methyltransferase -
OEE45_RS22725 (OEE45_22735) 4805614..4806165 - 552 WP_064405206.1 N-acetyltransferase Antitoxin
OEE45_RS22730 (OEE45_22740) 4806176..4806433 - 258 WP_004110819.1 YjhX family toxin Toxin
OEE45_RS22735 (OEE45_22745) 4807109..4808293 + 1185 WP_014228054.1 mannonate dehydratase -
OEE45_RS22740 (OEE45_22750) 4808367..4809851 + 1485 WP_064405208.1 fructuronate reductase -
OEE45_RS22745 (OEE45_22755) 4809990..4810766 + 777 WP_004847986.1 Uxu operon transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(22-130)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9552.07 Da        Isoelectric Point: 11.1381

>T266336 WP_004110819.1 NZ_CP114149:c4806433-4806176 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 184 a.a.        Molecular weight: 19976.78 Da        Isoelectric Point: 6.4897

>AT266336 WP_064405206.1 NZ_CP114149:c4806165-4805614 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQAVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPAAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Download         Length: 552 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H6Y2

Antitoxin

Source ID Structure

References