Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1988592..1989182 Replicon chromosome
Accession NZ_CP114149
Organism Klebsiella michiganensis strain 2022CK-00496

Toxin (Protein)


Gene name pemK Uniprot ID A0A1F2LYA2
Locus tag OEE45_RS09490 Protein ID WP_008804165.1
Coordinates 1988850..1989182 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag OEE45_RS09485 Protein ID WP_064405693.1
Coordinates 1988592..1988849 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE45_RS09475 (OEE45_09480) 1985916..1987871 - 1956 WP_064405695.1 hypothetical protein -
OEE45_RS09480 (OEE45_09485) 1988128..1988331 + 204 WP_224243742.1 helix-turn-helix domain-containing protein -
OEE45_RS09485 (OEE45_09490) 1988592..1988849 + 258 WP_064405693.1 hypothetical protein Antitoxin
OEE45_RS09490 (OEE45_09495) 1988850..1989182 + 333 WP_008804165.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
OEE45_RS09495 (OEE45_09500) 1990007..1990783 + 777 WP_073554415.1 sigma-70 family RNA polymerase sigma factor -
OEE45_RS09500 (OEE45_09505) 1990780..1991349 + 570 WP_218571335.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-109)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11867.71 Da        Isoelectric Point: 10.1839

>T266329 WP_008804165.1 NZ_CP114149:1988850-1989182 [Klebsiella michiganensis]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPRTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9452.97 Da        Isoelectric Point: 4.4607

>AT266329 WP_064405693.1 NZ_CP114149:1988592-1988849 [Klebsiella michiganensis]
MYTTRLKKVGGSIMLAVPPAVLKTLELSMDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2LYA2

Antitoxin

Source ID Structure

References