Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 841158..841815 Replicon chromosome
Accession NZ_CP114149
Organism Klebsiella michiganensis strain 2022CK-00496

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag OEE45_RS04045 Protein ID WP_064404221.1
Coordinates 841405..841815 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID H3N295
Locus tag OEE45_RS04040 Protein ID WP_004124953.1
Coordinates 841158..841424 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
OEE45_RS04025 (OEE45_04030) 836392..836817 - 426 WP_004854067.1 PTS sugar transporter subunit IIA -
OEE45_RS04030 (OEE45_04035) 836938..839736 - 2799 WP_014226794.1 transcriptional regulator DagR -
OEE45_RS04035 (OEE45_04040) 839930..840913 - 984 WP_014226793.1 tRNA-modifying protein YgfZ -
OEE45_RS04040 (OEE45_04045) 841158..841424 + 267 WP_004124953.1 FAD assembly factor SdhE Antitoxin
OEE45_RS04045 (OEE45_04050) 841405..841815 + 411 WP_064404221.1 protein YgfX Toxin
OEE45_RS04050 (OEE45_04055) 841824..842345 - 522 WP_014226792.1 flavodoxin FldB -
OEE45_RS04055 (OEE45_04060) 842467..843363 + 897 WP_004105555.1 site-specific tyrosine recombinase XerD -
OEE45_RS04060 (OEE45_04065) 843386..844099 + 714 WP_004854054.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
OEE45_RS04065 (OEE45_04070) 844105..845838 + 1734 WP_032751182.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16122.97 Da        Isoelectric Point: 10.9455

>T266328 WP_064404221.1 NZ_CP114149:841405-841815 [Klebsiella michiganensis]
VVLWQSDLRISWRAQWFSLLMHGVVAALVLLMPWPLSYTPLWLILLSLVVFDCVRSQRRIHARQGEIKLLIDSRLRWQKA
EWDIIGTPWVINSGMLLRLRNTENQRTQHLWVAADSMDSGEWRDLRRLVLLKPTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10411.88 Da        Isoelectric Point: 5.1296

>AT266328 WP_004124953.1 NZ_CP114149:841158-841424 [Klebsiella michiganensis]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDTLSDGDKALFIRLLENDDPDLFNWLMNHGEPADAELQRMVKLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H3L9

References