Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4499973..4500568 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name chpB Uniprot ID U9Y4M4
Locus tag N0F11_RS22380 Protein ID WP_000239579.1
Coordinates 4499973..4500323 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID Q8XCF3
Locus tag N0F11_RS22385 Protein ID WP_001223210.1
Coordinates 4500317..4500568 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS22360 (4495419) 4495419..4496441 - 1023 WP_001301928.1 ABC transporter permease -
N0F11_RS22365 (4496455) 4496455..4497957 - 1503 WP_000205806.1 sugar ABC transporter ATP-binding protein -
N0F11_RS22370 (4498097) 4498097..4499053 - 957 WP_000265942.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
N0F11_RS22375 (4499363) 4499363..4499893 + 531 WP_000055075.1 inorganic diphosphatase -
N0F11_RS22380 (4499973) 4499973..4500323 - 351 WP_000239579.1 endoribonuclease toxin ChpB Toxin
N0F11_RS22385 (4500317) 4500317..4500568 - 252 WP_001223210.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
N0F11_RS22390 (4500780) 4500780..4501121 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
N0F11_RS22395 (4501124) 4501124..4504903 - 3780 WP_000060930.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12511.45 Da        Isoelectric Point: 5.6219

>T266315 WP_000239579.1 NZ_CP114130:c4500323-4499973 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAADEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9299.64 Da        Isoelectric Point: 4.4201

>AT266315 WP_001223210.1 NZ_CP114130:c4500568-4500317 [Escherichia coli]
MRITIKRWGNSAGMVIPNIVMKELNLQPGQSVEVQVSNNQLILTPISRRYSLDELLAQCDMNAAELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0Y8A8

Antitoxin

Source ID Structure

References