Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 4252051..4252601 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name ccdB Uniprot ID D3H432
Locus tag N0F11_RS21330 Protein ID WP_001160975.1
Coordinates 4252051..4252365 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID V0VEX8
Locus tag N0F11_RS21335 Protein ID WP_000125566.1
Coordinates 4252368..4252601 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS21305 (4247726) 4247726..4249012 + 1287 WP_000800457.1 peptidylprolyl isomerase SurA -
N0F11_RS21310 (4249012) 4249012..4250001 + 990 WP_000241259.1 4-hydroxythreonine-4-phosphate dehydrogenase PdxA -
N0F11_RS21315 (4249998) 4249998..4250819 + 822 WP_001065380.1 16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))- dimethyltransferase RsmA -
N0F11_RS21320 (4250822) 4250822..4251199 + 378 WP_000610901.1 Co2+/Mg2+ efflux protein ApaG -
N0F11_RS21325 (4251206) 4251206..4252054 + 849 WP_000257187.1 bis(5'-nucleosyl)-tetraphosphatase (symmetrical) ApaH -
N0F11_RS21330 (4252051) 4252051..4252365 - 315 WP_001160975.1 CcdB family protein Toxin
N0F11_RS21335 (4252368) 4252368..4252601 - 234 WP_000125566.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
N0F11_RS21340 (4252687) 4252687..4253166 - 480 WP_000624372.1 type 3 dihydrofolate reductase -
N0F11_RS21345 (4253358) 4253358..4255220 - 1863 WP_000377184.1 glutathione-regulated potassium-efflux system protein KefC -
N0F11_RS21350 (4255213) 4255213..4255743 - 531 WP_064561975.1 glutathione-regulated potassium-efflux system oxidoreductase KefF -
N0F11_RS21355 (4255851) 4255851..4257182 - 1332 WP_001183177.1 MFS transporter -
N0F11_RS21360 (4257240) 4257240..4257527 - 288 WP_000203741.1 ferredoxin-like protein FixX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(8-77)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11711.76 Da        Isoelectric Point: 9.8517

>T266311 WP_001160975.1 NZ_CP114130:c4252365-4252051 [Escherichia coli]
MQFTVYRSRSRNAAFPFVIDVTSDIIGVINRRIVIPLTPIERFSRIRPPERLNPILLLVDGKEYVLMTHETATVPVNALG
TKFCDASAHRTLIKGALDFMLDGI

Download         Length: 315 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8530.53 Da        Isoelectric Point: 5.8062

>AT266311 WP_000125566.1 NZ_CP114130:c4252601-4252368 [Escherichia coli]
MTAKRTTQSVTVTVDRELVNRARDAGLNMSATLTVALNAELKKHAATRWREENAEAIAALNQLADETGCFSDEYRSF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LTM9

References