Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3727558..3728176 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag N0F11_RS18805 Protein ID WP_001291435.1
Coordinates 3727958..3728176 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag N0F11_RS18800 Protein ID WP_000344800.1
Coordinates 3727558..3727932 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS18790 (3722647) 3722647..3723840 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
N0F11_RS18795 (3723863) 3723863..3727012 + 3150 WP_001132452.1 efflux RND transporter permease AcrB -
N0F11_RS18800 (3727558) 3727558..3727932 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
N0F11_RS18805 (3727958) 3727958..3728176 + 219 WP_001291435.1 HHA domain-containing protein Toxin
N0F11_RS18810 (3728348) 3728348..3728899 + 552 WP_000102553.1 maltose O-acetyltransferase -
N0F11_RS18815 (3729015) 3729015..3729485 + 471 WP_000136192.1 YlaC family protein -
N0F11_RS18820 (3729649) 3729649..3731199 + 1551 WP_001301851.1 cyclic-guanylate-specific phosphodiesterase PdeB -
N0F11_RS18825 (3731241) 3731241..3731594 - 354 WP_000878140.1 DUF1428 domain-containing protein -
N0F11_RS18835 (3731973) 3731973..3732284 + 312 WP_000409911.1 MGMT family protein -
N0F11_RS18840 (3732317) 3732317..3732889 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T266309 WP_001291435.1 NZ_CP114130:3727958-3728176 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT266309 WP_000344800.1 NZ_CP114130:3727558-3727932 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References