Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3272953..3273658 Replicon chromosome
Accession NZ_CP114130
Organism Escherichia coli strain NJS001

Toxin (Protein)


Gene name relE Uniprot ID Q8X3N0
Locus tag N0F11_RS16715 Protein ID WP_000539519.1
Coordinates 3272953..3273339 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag N0F11_RS16720 Protein ID WP_001280945.1
Coordinates 3273329..3273658 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
N0F11_RS16695 (3268957) 3268957..3269583 + 627 WP_001295292.1 glutathione S-transferase GstB -
N0F11_RS16700 (3269580) 3269580..3270695 - 1116 WP_000554959.1 aldose sugar dehydrogenase YliI -
N0F11_RS16705 (3270806) 3270806..3271189 - 384 WP_000497137.1 biofilm formation regulator BssR -
N0F11_RS16710 (3271402) 3271402..3272727 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
N0F11_RS16715 (3272953) 3272953..3273339 + 387 WP_000539519.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
N0F11_RS16720 (3273329) 3273329..3273658 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
N0F11_RS16725 (3273728) 3273728..3275056 - 1329 WP_000086905.1 GGDEF domain-containing protein -
N0F11_RS16730 (3275064) 3275064..3277412 - 2349 WP_000950320.1 EAL domain-containing protein -
N0F11_RS16735 (3277590) 3277590..3278501 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14279.42 Da        Isoelectric Point: 9.9296

>T266308 WP_000539519.1 NZ_CP114130:3272953-3273339 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGSKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT266308 WP_001280945.1 NZ_CP114130:3273329-3273658 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References